Ultrasound vs MRI for Early Liver Cancer Detection

Preventing Liver Cancer Mortality Through Imaging With Ultrasound vs. MRI

Recruiting N/A Interventional Study
Carcinoma, Hepatocellular Cirrhosis
No Placebo Group Every participant receives an active treatment — no one gets a placebo.
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At a Glance
Age
18 – 75
Sex
Any
Study type
Interventional
Purpose
Prevention
Participants needed
4,700 (estimated)
Sponsor
VA Office of Research and Development · Federal
Who this trial is looking for

This trial is looking for people with cirrhosis to compare two different methods for early detection of liver cancer. Participants will undergo imaging tests to see which method works better at spotting cancer earlier.

Are You a Good Fit for This Trial?

You may be able to join if

  • I have been diagnosed with cirrhosis.
  • I am between 18 and 75 years old.
  • I can provide informed consent.
  • I have a high risk of liver cancer.

You may not be able to join if

  • I have had a diagnosis of liver cancer before.
  • I currently have a suspicion of liver cancer.
  • I have received an organ transplant.
  • I am currently pregnant.
  • I cannot have an MRI due to allergies or devices in my body.

Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.

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About This Trial
The study is a randomized trial of two different screening methods for early detection of liver cancer in patients with cirrhosis of the liver. The goal of PREMIUM is to compare an abbreviated version of the diagnostic gold standard for HCC (aMRI) +AFP to the standard-of-care screening (US+AFP) in patients at high risk of developing HCC. The investigators hypothesize that HCC will be detected at e…
Trial Locations
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Eligibility Criteria
Inclusion Criteria: 1. Cirrhosis due to any underlying etiology diagnosed by one or more of the following: * Histology of liver biopsy * Radiologic criteria (nodular liver, evidence of portal hypertension) * Clinical signs of cirrhosis (gastroesophageal varices, ascites, hepatic encephalo…
Contacts

George N Ioannou, MD MS

(206) 277-3136

George.Ioannou@va.gov

CONTACT