RM1 Project 1 - tAN Naloxone
Recruiting
Early Phase 1
Interventional Study
Analgesia
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
At a Glance
- Age
- 18 – 65
- Sex
- Any
- Trial phase
- Early Phase 1
- Study type
- Interventional
- Purpose
- Treatment
- Participants needed
- 136 (estimated)
- Sponsor
- Medical University of South Carolina · Other
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About This Trial
This two-visit, randomized, double-blind, sham-controlled trial, uses a novel naloxone blockade model in 136 individuals to determine whether the analgesic effects of a 30-minute transcutaneous auricular neurostimulation (tAN) intervention are mediated through a release of endogenous opioids. Analgesic effects of four various stimulation interventions will be measured (auricular vagus, auricular t…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Age 18-65
* Have the capacity and ability to provide one's own consent and sign the informed consent document
Exclusion Criteria:
* Contraindicated for MRI.
* Any current or recent untreated medical, neurological, or psychiatric conditions
* Metal implant devices in the head…
Contacts