Use of Leukocyte-Rich PRP or Leukocyte-Free PRP in the Treatment of Hip Osteoarthritis

Inclusion Criteria: * Signs and symptoms of hip OA (pain intensity of at least 4 points and not more than 8 of VAS pain - 0-10 scale in the previous week); * Radiographic signs of hip OA (Grade 1-2 according to Tonnis classification) or MRI signs (chondropathy or minimal labrum degeneration without acute lesions) even if Grade 0. * Unilateral involvement; Hemoglobin \> 11 g/dl; * Platelet count \> 150,000 plt/mm3 (Recently performed CBC examination); * Negative serological tests for HBsAg, HCV Ab, HIV-1-2 Ab * No clinically significant electrocardiographic changes (Recently performed ECG). * Ability and consent of patients to actively participate in clinical follow-up;- Signature of informed consent. Exclusion Criteria: * Patients unable to express consent; * Patients undergoing infiltration of other substance in the previous 6 months; * Patients undergoing lower limb surgery to be treated in the previous 12 months; * Patients with malignant neoplasms; * Patients with rheumatic diseases;- Patients with uncontrolled diabetes;-Patients with hematological diseases (coagulopathies); * Patients on anticoagulant-antiaggregant therapy that cannot be discontinued for at least 3 days prior to blood collection; * Patients with uncontrolled thyroid metabolic disorders; * Patients abusing alcoholic beverages, drugs or medications; * Body Mass Index \> 30; * Patients who have taken NSAIDs in the 3 days prior to blood draw; * Patients with cardiovascular disease for whom 300 ml blood draw would be contraindicated; * Patients with recently performed CBC examination with Hb\< 11 g/dl and Platelet values \< 150,000 plt/mm3. * Positive serological tests for HBsAg, HCV Ab, HIV-1-2 Ab * Pregnant and/or fertile women. * Pain intensity less than 4 points or greater than 8 in accordance with the VAS scale. * Patients with other hip pathologies: acetabular protrusion, concentric migration of the femoral head, presence of excessive deformity resulting from acetabular or femoral head dysplasia, collapse deformity, and deformed femoral head sequelae of Perthes disease or osteonecrosis of the femoral head. * Previous extensive surgery of the reference joint (osteotomy around the hip, open or arthroscopic osteochondroplasty for femoro-acetabular conflict).