Functional Study to Indentify Genetic Etiology of Rare Diseases - ORIGIN

Inclusion Criteria: Patient : * Child or adult affected by a rare disease whose molecular functions are not known, or whose pathophysiologic mechanism are not fully understood. * Patient included inside the BaMaRa (French rare disease national data bank) database dedicated to the rare diseases. * Patient Affiliated to the French social security system. * Patient consent form or legal representative consent form obtained. Patient's parent : * Parent of a patient affected by a rare disease whose molecular functions are not known, or whose pathophysiologic mechanism are not fully understood. * Parent included in the BaMaRa database. * Parent affiliated to the French social security system. * Parent consent form obtained for himself/herself. Patient's brother or sister : * Brother or sister of a patient (underage or adult) affected by a rare disease whose molecular functions are not known, or whose pathophysiologic mechanism are not fully understood. * Brother or sister included in the BaMaRa database. * Brother or sister affiliated to the French social security system. * Brother or sister consent form obtained for themselves or from their legal representative. Exclusion Criteria: * Poor understanding of the French language * Legal of administrative liberty deprivation * Psychiatric force care