Buspirone for Opioid Withdrawal Treatment
Evaluating Buspirone to Treat Opioid Withdrawal
Recruiting
Phase 2
Interventional Study
Opioid Use Disorder
Opioid Withdrawal
Opioid Craving
Anxiety
Prior Safety Data
This treatment has already been tested in at least one earlier human trial.
At a Glance
- Age
- 18 – 75
- Sex
- Any
- Trial phase
- Phase 2
- Study type
- Interventional
- Purpose
- Treatment
- Participants needed
- 100 (estimated)
- Sponsor
- University of Maryland, Baltimore · Other
Who this trial is looking for
This trial is looking for adults aged 18 to 75 who have a dependence on opioids and want to detoxify. Participants will stay in a residential facility for 10 to 12 days to gradually reduce their opioid use while being closely monitored.
Are You a Good Fit for This Trial?
You may be able to join if
- I am between 18 and 75 years old.
- I have a positive urine test for opioids.
- I have moderate to severe opioid use disorder.
- I am interested in detoxifying from opioids.
You may not be able to join if
- I am pregnant or breastfeeding.
- I am currently receiving methadone or buprenorphine treatment.
- I am allergic to the study medication.
- I have a serious mental health or physical problem that would affect my participation.
- I have low blood pressure.
- I have a prolonged QTc interval.
Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.
Think this trial could be right for you?
Answer a few quick questions to see if you may meet the eligibility requirements.
Check Your Eligibility
About This Trial
The investigators propose a rigorous, Phase II, three-group, placebo-controlled double-blind randomized controlled trial (RCT) to evaluate the efficacy of buspirone for both withdrawal and craving among individuals with opioid use disorder (OUD) undergoing a standardized stepwise taper. During this 10 to 12-day residential study, participants with OUD will be enrolled, stabilized on a short-acting…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Aged 18-75
* Opioid positive urine sample
* Current moderate-severe opioid use disorder with evidence of physical dependence
* Interested in undergoing opioid detoxification
Exclusion Criteria:
* Being pregnant or breastfeeding
* Enrolled in methadone or buprenorphine mainte…
Contacts