Smoking Cessation and Menstrual Cycle Phase

Inclusion Criteria: * Must provide informed consent following the CAMH REDCap e-consent framework and procedures; * Stated willingness to comply with all study procedures; * Naturally cycling individuals with regular MCs (defined as length ranging 21 to 35 days over past 6 months); * Daily smoker of ≥5 cigarettes per day (CPD) over past 6 months; * Intention to quit smoking within the next 30 days and willing to make a quit attempt on their assigned TQD; * Interested in using, and able to use, nicotine patches and gum or lozenge as a smoking cessation aid; * Willing to provide a valid e-mail address to be used for study communications and to complete online questionnaires. Exclusion Criteria: * Current use of progesterone, estrogen, testosterone, or fertility treatment; * Current use of nicotine replacement therapy or other smoking cessation medications (e.g., varenicline, bupropion); * Use of hormonal contraceptives in the past 6 months (e.g., pill, patch, hormonal intrauterine device \[IUD\], ring); * Pregnancy, or trying to become pregnant in the next 2-3 months; * Known hypersensitivity or allergies to any of the components of the nicotine patch; * Daily or almost daily use of cannabis in the past 6 months; * Daily or almost daily use of tobacco or nicotine products other than cigarettes (e.g., smokeless tobacco, heat-not-burn products, e-cigarettes) in the past 6 months; * Polycystic ovary syndrome diagnosis; * Unstable psychiatric condition (including substance use disorder) which would compromise study compliance; * Life threatening arrhythmias or severe/worsening angina pectoris; * Myocardial infarction or cerebral vascular accident in the past 2 weeks; or * Diagnosed with a terminal illness.