Dronabinol for Sickle Cell Pain and Inflammation

Cannabinoids for the Reduction of Inflammation and Sickle Cell Related Pain

Recruiting Phase 2 Interventional Study
Sickle Cell Disease
Prior Safety Data This treatment has already been tested in at least one earlier human trial.
Ready to participate?

Review the details below, then apply to join this clinical trial.

At a Glance
Age
18 and older
Sex
Any
Trial phase
Phase 2
Study type
Interventional
Purpose
Supportive Care
Participants needed
60 (estimated)
Sponsor
Icahn School of Medicine at Mount Sinai · Other
Who this trial is looking for

This trial is looking for adults with sickle cell disease who experience pain and inflammation. Participants will take dronabinol to see if it helps reduce their symptoms over a period of 8 weeks.

Are You a Good Fit for This Trial?

You may be able to join if

  • I am over 18 years old
  • I have sickle cell disease
  • I have a pain score of 60 or lower
  • I have been on my sickle cell treatment for at least 3 months
  • I have been taking my pain medication for at least 3 months
  • I can consent to participate in research
  • I am willing to use birth control if I can become pregnant

You may not be able to join if

  • I have had issues with dronabinol or marijuana in the past
  • I have a history of psychosis or suicidal thoughts
  • I cannot take dronabinol because of other medications or health problems
  • I am pregnant or nursing
  • I use cannabis daily
  • I have an active substance use disorder

Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.

Think this trial could be right for you?

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About This Trial

A randomized, double blind, study of dronabinol as a palliative agent in the treatment of pain, inflammation, and other complications of sickle cell disease (SCD).

Trial Locations
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Eligibility Criteria
* Age \>18 years * Clinical diagnosis of SCD (HbSS, HbSC, HbSβ+; Thal, HbSβ0Thal, HbS variants) * Baseline score of 60 or lower on the ASCQ-Me 7-day pain interference domain * If on a SCD modifying therapy (hydroxyurea, regular blood transfusions, L-glutamine, voxelotor, crizanlizumab), on stable do…
Contacts

Susanna Curtis, MD, PhD

2036718154

susanna.curtis@mssm.edu

CONTACT