Examining Blood and Tissue Samples to Identify Diagnostic Markers in Patients With Metastatic Cancer Undergoing Tumor Removal

Inclusion Criteria: * Patients (or the legally authorized representative/guardian signing on behalf of the participant) must understand and provide written informed consent prior to initiation of any study-specific procedures * \>= 18 years of age * Patients must have a diagnosis of confirmed malignancy * Patient is a good medical candidate for a standard of care biopsy or surgical procedure to obtain tissue or has archival tissue available for analysis Exclusion Criteria: * Uncontrolled concurrent illness including psychiatric illness, or situations that would limit compliance with the study requirements or the ability to willingly give written informed consent * Inaccessible tumor for biopsy or patient does not have tumor tissue available for research use * Biopsy must not be considered to be more than minimal risk to the patient. Contraindications to percutaneous biopsy: * Significant coagulopathy that cannot be adequately corrected * Severely compromised cardiopulmonary function or hemodynamic instability * Lack of a safe pathway to the lesion * Inability of the patient to cooperate with, or to be positioned for, the procedure