ctDNA Methylation Application in Postoperative Relapse and Adjuvant Chemotherapy Efficacy Evaluation

Inclusion Criteria: * Patients must have histologically confirmed stage I/II (without high risk) colorectal cancer. * Male or female ≥ 18 years of age on the day of signing informed consent. * Patients need to receive surgical resection, and with ctDNA positive prior to resection of colorectal cancer (CRC). * Patients must have a performance status of ≤1 on the Eastern Cooperative Oncology Group (ECOG) Performance Scale. * Written informed consent must be obtained from patient or patient's legal representative and ability for patient to comply with the requirements of the study. Exclusion Criteria: * Personal history of colorectal cancer, colorectal adenoma or aerodigestive tract cancer. * Induction of neoadjuvant systemic therapy prior to resection of CRC. * Patient is pregnant or lactating. * Patients with a history or current evidence of any condition or abnormality that might confound the results of the study, interfere with the patient's participation for the full duration of the study, or is not in the best interest of the patient to participate, in the opinion of the Investigator. * Inadequate tumor material (either quality and quantity) to support circulating tumor DNA (ctDNA) analysis.