Urinary Prostaglandin as a Potential Predictive Marker for Thiazide-induced Hyponatremia
Recruiting
Observational Study
Thiazide-induced Hyponatremia (TIH)
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
At a Glance
- Age
- 18 and older
- Sex
- Any
- Study type
- Observational
- Participants needed
- 232 (estimated)
- Sponsor
- University Hospital, Basel, Switzerland · Other
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About This Trial
Thiazides and thiazide-like diuretics are one of the five major classes of antihypertensive drugs. This study is to investigate whether urinary PGE2 concentration at baseline (prior to thiazide initiation) is associated with the development of TIH within the first four weeks of treatment.
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Newly prescribed thiazide or thiazide-like diuretic
* ≥ 18 years of age
* Informed Consent as documented by signature
Exclusion Criteria:
* Intake of thiazide or thiazide-like diuretic in the preceding month
* Hyponatremia (plasma sodium \<135 mmol/L) at baseline
* Acute inf…
Contacts