No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
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At a Glance
Age
21 – 89
Sex
Any
Study type
Interventional
Purpose
Treatment
Participants needed
24 (estimated)
Sponsor
University of Minnesota · Other
Who this trial is looking for
This trial is looking for people with Parkinson's disease who have had surgery to implant deep brain stimulators. Participants will help researchers understand how different locations of stimulation affect motor symptoms.
Are You a Good Fit for This Trial?
You may be able to join if
I have been diagnosed with Parkinson's disease.
I have undergone surgery to implant deep brain stimulators.
I have existing 7T brain imaging.
You may not be able to join if
I have a history of movement issues due to musculoskeletal disorders.
I have another significant neurological disorder.
I have a history of dementia or cognitive impairment.
I have had post-operative complications or adverse effects.
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
This protocol will characterize the effects of deep brain stimulation (DBS) location (both adverse and beneficial) on motor signs in people with Parkinson's disease (PD). This information can be used to inform future DBS protocols to tailor stimulation to the specific needs of a patient. If targeted dorsal GP stimulation is shown to significantly improve motor features that are typically resistant…
This protocol will characterize the effects of deep brain stimulation (DBS) location (both adverse and beneficial) on motor signs in people with Parkinson's disease (PD). This information can be used to inform future DBS protocols to tailor stimulation to the specific needs of a patient. If targeted dorsal GP stimulation is shown to significantly improve motor features that are typically resistant to dopamine replacement therapy, these experiments will likely have major impact on clinical practice by providing a potential strategy to these medically intractable symptoms.
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* diagnosis of idiopathic PD
* have undergone neurosurgery to implant deep brain stimulators in the globus pallidus (GP DBS) or subthalamic nucleus (STN)
* Existing 7T brain imagery
Exclusion Criteria:
* history of musculoskeletal disorders that significantly affect movement o…
Inclusion Criteria:
* diagnosis of idiopathic PD
* have undergone neurosurgery to implant deep brain stimulators in the globus pallidus (GP DBS) or subthalamic nucleus (STN)
* Existing 7T brain imagery
Exclusion Criteria:
* history of musculoskeletal disorders that significantly affect movement of the upper or lower limbs
* other significant neurological disorder
* history of dementia or cognitive impairment as found with UBACC (or MacCAT-CR)
* post-operative complications or adverse effects
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