Linking Brain Network Dynamics to Imminent Smoking Lapse Risk and Behavior
Recruiting
N/AInterventional Study
SmokingTobacco Use
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
21 – 65
Sex
Any
Study type
Interventional
Purpose
Basic Science
Participants needed
150 (estimated)
Sponsor
Penn State University · Other
Who this trial is looking for
This trial is looking for adult smokers who want to understand what leads to smoking lapses. Participants will undergo brain scans while discussing their smoking behavior to help researchers learn how brain activity relates to smoking lapses.
Are You a Good Fit for This Trial?
You may be able to join if
I am between 21 and 65 years old.
I speak fluent English.
I can safely undergo an MRI.
I smoke at least six cigarettes a day for the past year.
My carbon monoxide level is above 10 parts per million.
You may not be able to join if
I cannot refrain from using nicotine for 12 hours before the visit.
I have a pacemaker or metal objects in my body.
I have a history of having metallic fragments that could affect MRI scans.
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
Most attempts to quit smoking end in relapse, or a return to regular smoking. One of the biggest threats to cessation is a lapse (i.e., any cigarette use during a quit attempt). Thus, characterizing why lapses occur is essential to understanding and preventing smoking relapse. Functional magnetic resonance imaging (fMRI) is a promising method for characterizing the psychological processes that lea…
Most attempts to quit smoking end in relapse, or a return to regular smoking. One of the biggest threats to cessation is a lapse (i.e., any cigarette use during a quit attempt). Thus, characterizing why lapses occur is essential to understanding and preventing smoking relapse. Functional magnetic resonance imaging (fMRI) is a promising method for characterizing the psychological processes that lead to smoking lapses because it provides a way to measures patterns of brain activity thought to reflect relevant mental processes as they change over time. However, methodological issues have hindered the ability to capitalize on this potential and prevented an understanding of how brain activity and corresponding psychological processes unfold in the critical moments that immediately precede a smoking lapse. The proposed project will address this knowledge gap using a novel fMRI paradigm adapted from a well-validated behavioral lapse task. The goals of the project are to characterize changes in brain activity that lead up to a lapse and to investigate how these changes are related to concurrent affect and subsequent cigarette use.
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Eligibility Criteria
Inclusion Criteria:
* Participants must be between the ages of 21 and 65.
* Participants must be fluent English speakers.
* Participants must pass an MRI safety screening.
* Participants must report smoking at least six cigarettes per day continuously for at least the 12 preceding months.
* Partici…
Inclusion Criteria:
* Participants must be between the ages of 21 and 65.
* Participants must be fluent English speakers.
* Participants must pass an MRI safety screening.
* Participants must report smoking at least six cigarettes per day continuously for at least the 12 preceding months.
* Participants must have a baseline expired-air carbon monoxide exceeding 10 parts per million in order to verify smoking status.
Exclusion Criteria:
* Individuals will be excluded if they report that they are not willing to refrain from using nicotine for 12 hours before the experimental lab visit.
* Individuals will be excluded if they have any known risk from exposure to high-field strength magnetic fields (e.g., pacemakers), any irremovable metallic foreign objects in their body (e.g., braces), or a questionable history of metallic fragments that are likely to create artifact on the MRI scans.
Contacts
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