Behavioral Activation for Depression in Older Cancer Survivors
A Study of Brief Behavioral Activation for the Treatment of Depression in Older Adult Cancer Survivors
Recruiting
N/AInterventional Study
Survivorship
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
65 and older
Sex
Any
Study type
Interventional
Purpose
Treatment
Participants needed
150 (estimated)
Sponsor
Memorial Sloan Kettering Cancer Center · Other
Who this trial is looking for
This trial is looking for older adults who have survived cancer and experience depression. Participants will receive therapy sessions by phone or video to help improve their mood.
Are You a Good Fit for This Trial?
You may be able to join if
I am 65 years or older.
I have a history of cancer.
I have no evidence of disease or have been cancer-free for at least 6 months.
I can communicate well in English.
I can participate in sessions by phone or video.
I have a score of 5 or higher on the PHQ-9 test for depression.
I have a score of 11 or lower on the Blessed Orientation-Memory-Concentration Scale.
You may not be able to join if
I have current thoughts of hurting myself or others.
I have a major untreated psychotic disorder.
I am currently taking antidepressant medication for less than 3 months.
I have impaired decision-making capacity.
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
The purpose of this study is to find out if a psychotherapy method called behavioral activation (BA) can be successfully delivered by telephone or videoconference (remotely) and can effectively treat depression in Older Adult Cancer Survivors (OACS)
Trial Locations
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Status
Eligibility Criteria
Inclusion Criteria:
Phase I:
* As per self-report or medical record, ≥65 years old
* As per self-report or medical record, has a history of cancer
* As per medical record and/or clinician confirmation:
* a patient in MSK Survivorship Clinics AND/OR
* no evidence of disease (NED) AND/OR
* 6 …
Inclusion Criteria:
Phase I:
* As per self-report or medical record, ≥65 years old
* As per self-report or medical record, has a history of cancer
* As per medical record and/or clinician confirmation:
* a patient in MSK Survivorship Clinics AND/OR
* no evidence of disease (NED) AND/OR
* 6 months or more post-treatment (patients on maintenance hormonal therapies are eligible)
* Fluent in English, as per self-reported fluency of "well" or "very well"\*
* As per self-report, able to communicate over video-conference and/or phone for sessions
* Elevated score on the PHQ-9: ≥5 (N/A for Training Case participants)
* Received a Blessed Orientation-Memory-Concentration Scale (BOMC) score of ≤ 11 (N/A for Training Case participants)
Phase II:
* As per self-report or medical record, ≥18 years old
* Fluent in English, as per self-reported fluency of "well" or "very well"\*
* As per self-report or medical record, has a history of cancer
* Elevated score on the PHQ-9: ≥5
* Received a Blessed Orientation-Memory-Concentration Scale (BOMC) score of ≤ 11 (N/A for Training Case participants)
Note. The eligibility criteria for Phase II allows inclusion of younger participants and those receiving active treatment due to the theoretical rationale that a single-session intervention will remove certain barriers that are believed to exist for these groups in receiving the longer, 10-session intervention.
Exclusion Criteria:
Phase I:
* As per PI determination, requires a higher level of care for current passive or active suicidal ideation than current protocol is able to provide. If a participant receives a score of \> 0 on item 9 of the PHQ-9, they will be referred to study PI for further evaluation. They will be excluded from participation in this study if the PI determines they would be appropriate for a higher level of care than BA may be able to provide.
* As per self-report or as documented in the medical record, current untreated (e.g., no medication, no therapy) major psychotic disorder (schizotypal personality disorder, schizophreniform disorder, schizoaffective disorder). Patients diagnosed with a major psychiatric disorder will be reviewed by the study PI to determine eligibility prior to consent.
* As per self-report or medical record, currently taking antidepressant medication for \< 3 month
* As per medical record, patient has impaired decision-making capacity
Phase II:
* As per PI determination, requires a higher level of care for current active suicidal ideation than current protocol is able to provide. If a participant receives a score of \> 0 on item 9 of the PHQ-9, they will be referred to study PI for further evaluation. They will be excluded from participation in this study if the PI determines they would be appropriate for a higher level of care than BA may be able to provide.
* As per self-report or medical record, current weekly psychotherapy or currently taking an antidepressant for \<3 months.
* As per medical record, patient has impaired decision-making capacity
* Language verification: Prior to enrollment, patients will be asked the following two questions by research staff to verify English fluency necessary for participation in the study:
1. How well do you speak English? (must respond "Well" or "Very well" when given the choices of Very well, Well, Not well, Not at all, Don't know, or Refused)
2. What is your preferred language for healthcare? (must respond English)
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