Neoadjuvant Therapy for Operable Breast Cancer
Fudan University Shanghai Cancer Center Breast Cancer Precision Platform Series Study- Neoadjuvant Therapy
Recruiting
Phase 2
Interventional Study
Breast Neoplasm
Breast Cancer
Breast Tumors
Triple-Negative Breast Cancer (TNBC)
HER2-positive Breast Cancer
HER2-negative Breast Cancer
Hormone Receptor Positive Tumor
Hormone Receptor Negative Tumor
Early-stage Breast Cancer
Locally Advanced Breast Cancer
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Prior Safety Data
This treatment has already been tested in at least one earlier human trial.
At a Glance
- Age
- 18 – 70
- Sex
- Female
- Trial phase
- Phase 2
- Study type
- Interventional
- Purpose
- Treatment
- Participants needed
- 716 (estimated)
- Sponsor
- Fudan University · Other
Who this trial is looking for
This trial is looking for people with operable breast cancer to explore a new treatment approach. Participants will receive a targeted therapy before surgery and help researchers understand how effective it is.
Are You a Good Fit for This Trial?
You may be able to join if
- I have been diagnosed with invasive breast cancer stage T1-4N1-3M0 or cT2-4N0M0
- I am between 18 and 70 years old
- I have a performance status of 0-1
- I have measurable lesions according to standard criteria
- I have normal organ and marrow function
- I am not pregnant or breastfeeding and will use contraception during the study
- I can understand and sign a consent form
You may not be able to join if
- I have received previous chemotherapy, hormone therapy, or radiation
- I have heart disease that is classified as NYHA grade II or above
- I have severe infections or other serious diseases
- I am allergic or intolerant to the study drug or its components
- I have had other cancers in the last 5 years, except for certain cured cancers
- I am pregnant or breastfeeding and refuse to use contraception
- I participated in other trials within the last 30 days
- I have been judged by the investigator to be unsuitable for this study
Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.
Think this trial could be right for you?
Answer a few quick questions to see if you may meet the eligibility requirements.
Check Your Eligibility
About This Trial
The purpose of this study is to establish a prospective, single-center platform research based on clinical subtypes to explore precision neoadjuvant therapy in patients with operable breast cancer who met the indications for neoadjuvant chemotherapy and by the update of basic translational research in the center, especially the refinement of typing, the discovery of new targets and the development…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Histologically confirmed invasive breast cancer of clinical stage T1-4N1-3M0 or cT2-4N0M0;
* Age between18-70 years;
* Eastern Cooperative Oncology Group (ECOG) performance status 0-1;
* ER, PR and HER2 status were measured by immunohistochemistry (IHC);
* LVEF≥55%；
* Definiti…
Contacts