Treatment Response Biomarkers in MDD

Inclusion Criteria: 1. The subject is an outpatient/inpatient (but the subject who participated in the experimental treatment does not need to be hospitalized), and passed M.I.N.I. interview confirmed that the subjects met DSM-5 diagnostic criteria of current or past major depressive disorder. 2. Age 18-60 years old, regardless of gender; 3. Right-handed; 4. Junior high school education or above, capable of completing informed consent and cognitive test; 5. During the follow-up period, the subjects can take antidepressant treatment according to the doctor's advice of outpatient or resident. \- Exclusion Criteria: 1. Patients with psychotic symptoms; 2. M.I.N.I. was diagnosed as schizophrenia, schizophrenic affective disorder, schizophrenia-like disorder, Paranoia or current mental symptoms, post-traumatic stress disorder (currently or within the past year) or dysthymia; 3. with brain organic and serious physical diseases (such as thyroid disease, lupus erythematosus, diabetes, lung, liver and kidney) damage, infection, major trauma, etc.) exclude intracranial implants; 4. Clinically significant sensory disturbance that can't be corrected (for example, hearing impairment makes conversation impossible); 5. Pregnant and lactating women; -