Sit-stand Desk Program for Prediabetes and Obesity

At a Glance

Age: 18 – 79
Sex: Any
Study type: Interventional
Purpose: Prevention
Participants needed: 198 (estimated)
Sponsor: Medical College of Wisconsin · Other

Who this trial is looking for

This trial is looking for adults with prediabetes or obesity who have office jobs that involve a lot of sitting. Participants will use a sit-stand desk at work and see if it helps improve their health over time.

Are You a Good Fit for This Trial?

You may be able to join if

I am overweight or obese (BMI of 25 or higher)
I work a job where I sit for at least 75% of my workday
I have been diagnosed with prediabetes or have other diabetes risk factors
I am at least 45 years old or have a family history of diabetes
I do not engage in regular exercise
I identify as a member of certain ethnic groups at higher risk for diabetes

You may not be able to join if

I have heart disease or heart failure
I have diabetes or take diabetes medications
I have serious joint problems
I have neuropathy or fainting issues
I smoke tobacco or use recreational drugs
I am pregnant, breastfeeding, or plan to become pregnant soon
I have high triglycerides or uncontrolled high blood pressure
I do not speak English

Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.

About This Trial

More than 84 million - or 1 out of every 3 U.S. adults - have prediabetes, a condition that if not treated often leads to type 2 diabetes within five years. Average medical expenditures among diabetics are about 2.3 times higher than expenditures for people without diabetes. Physical inactivity and elevated body mass index (BMI) are major risk factors for the disease. Sedentary behavior is becomin…

More than 84 million - or 1 out of every 3 U.S. adults - have prediabetes, a condition that if not treated often leads to type 2 diabetes within five years. Average medical expenditures among diabetics are about 2.3 times higher than expenditures for people without diabetes. Physical inactivity and elevated body mass index (BMI) are major risk factors for the disease. Sedentary behavior is becoming increasingly prevalent with the growth of a 'work from home' culture, most recently driven by the COVID-19 pandemic. Cross-sectional epidemiologic data report significant associations between high amounts of sedentary (sitting) time and prevalent cardiovascular disease and diabetes. In our pilot study of 15 subjects with sedentary office jobs, 6 months of sit-stand desk use resulted in a 23% improvement in insulin resistance, most substantial in those who decreased daily sitting by over 90 minutes/day. Additional improvements in vascular endothelial function and triglyceride levels were seen without any change in exercise activity, step counts, or body weight. These findings not only corroborate epidemiologic findings on this topic but suggest causality and warrant a randomized control trial. The investigators hypothesize that adult subjects at-risk for diabetes will improve insulin sensitivity, metabolic and vascular (endothelial) health with a sit-stand desk intervention at work (whether in the office or at home), in the context of a randomized, controlled trial. The investigators will randomize 198 sedentary office workers with a BMI≥25 at risk for type 2 diabetes mellitus in a 1:1:1 ratio of three groups: (a) sit-stand desk intervention targeting 2 hours standing per day; (b) sit-stand desk intervention targeting 3 hours standing per day; or (c) control arm over 6 months. The block randomization design will allow for important dose-response analyses. The investigators will objectively quantify standing time, sedentary time, sedentary bouts, daily steps, and exercise activity times using a compact and re-usable accelerometer that adheres to the subject's thigh. This will provide objective assessments of activity levels and sedentary times for 7 full days each at baseline, 3 and 6 months. The device is equipped with an inclinometer to classify posture (sitting verses standing).

Trial Locations

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Eligibility Criteria

Inclusion Criteria: 1. Overweight or obese (body mass index of 25 kg/m2 or higher) 2. Employees with "sedentary" jobs, defined as spending at least 75% of their (8 hours or more) workday sitting at a desk (at home or in an office) 3. Defined as "at-risk" for diabetes, defined as either: 1. Pred…

Inclusion Criteria: 1. Overweight or obese (body mass index of 25 kg/m2 or higher) 2. Employees with "sedentary" jobs, defined as spending at least 75% of their (8 hours or more) workday sitting at a desk (at home or in an office) 3. Defined as "at-risk" for diabetes, defined as either: 1. Prediabetes (HbA1c of 5.7% to 6.4%) or a fasting glucose of 100 to 125 mg/dL 2. Having one or more additional risk factors: (beyond BMI\>25) * Age 45 years or older * Family history of diabetes mellitus in a first-degree relative * Physical inactivity (no structured exercise activity) * History of gestational diabetes, hypertension, or dyslipidemia * African American, Alaska Native, American Indian, Asian American, Hispanic/Latino, Native Hawaiian, or Pacific Islander ethnicity Exclusion Criteria: 1. Established cardiovascular disease (myocardial infarction, coronary stent, coronary artery bypass grafting, cardiac transplant, or angina) 2. Established congestive heart failure or cardiomyopathy 3. Established peripheral vascular disease 4. Established diabetes (HbA1c ≥ 6.5% or on diabetes medications or insulin) 5. Chronic musculoskeletal disorders involving the lower extremities, such as arthritis of the knees or hips, or regular use of ambulatory assist devices such as a walker or cane 6. Neuropathy of any etiology 7. Positional syncope or history of orthostasis 8. Less than 4 days/week at any single office (or work-from-home) location. 9. Current use of a standing desk for work 10. Tobacco use within the previous 12 months 11. Current illicit drug use or excessive alcohol use (defined as more than 14 drinks/week for women, more than 28 drinks/week for men) 12. Steroid use ≥21 days/year 13. Fasting triglyceride level ≥ 500 mg/dL 14. Thyroid disease 15. Uncontrolled or untreated hypertension(\>150/90 mm Hg) 16. Pregnant or lactating (or plans to become pregnant in the next 6 months) 17. LDL cholesterol ≥ 190mg/dL 18. Currently enrolled or plans to diet or join a weight loss program over the next 6 months. 19. Non-English speaker

Contacts

Jacquelyn Kulinski, MD

414-955-6896

jakulinski@mcw.edu

CONTACT

Ryan Kacala

414-955-6885

rkacala@mcw.edu

CONTACT

Sit-stand Desk Program for Prediabetes and Obesity

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