No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
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At a Glance
Age
18 and older
Sex
Any
Study type
Observational
Participants needed
380 (estimated)
Sponsor
Assistance Publique - Hôpitaux de Paris · Other
Who this trial is looking for
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* Testing the association between circulating candidate proteins and the level of vascular leakage for three distinct forms of circulatory failure: cardiogenic shock, septic shock, and post-resuscitation syndrome.
* Describing immuno-inflammatory profiles associated with massive vascular leakage during those three forms of circulatory failure in humans
Trial Locations
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Status
Eligibility Criteria
Inclusion Criteria:
1. Informed consent from patient or a legal representative/family member/close relative. The patient will be asked to give his/her consent for the continuation of the trial when his/her condition will allow.
2. Affiliation to social security (AME excluded)
3. Patient with one of…
Inclusion Criteria:
1. Informed consent from patient or a legal representative/family member/close relative. The patient will be asked to give his/her consent for the continuation of the trial when his/her condition will allow.
2. Affiliation to social security (AME excluded)
3. Patient with one of the circulatory failures described below:
* septic shock
* cardiogenic shock
* post-resuscitation syndrome
* Cardiogenic shock:
* Need for a catecholamine support to maintain mean arterial pressure\>65 mmHg, AND
* Cardiac index \<2 L/min/m2 or left ventricular ejection fraction (LVEF)\<35%, AND
* Lactate \>2.0 mmol/l
* Post-resuscitation syndrome:
* Cardiac arrest (absence of spontaneous respiration, palpable heartbeat, and responsiveness to stimuli\> 1 min) with a compatible electrocardiogram (asystole/pulseless electrical activity/ventricular tachycardia), AND
* Need for a catecholamine support to maintain mean arterial pressure\>65 mmHg, AND
* Lactate \>2.0 mmol/l
* Septic shock:
* Suspected or proven bacterial infection
* Need for a vasopressor support to maintain mean arterial pressure\>65 mmHg
* Lactate \>2.0 mmol/l
* Cardiac index\>3L/min/m2 or LVEF\>40%
Exclusion Criteria:
1. Onset of shock (catecholamine infusion) \>12 hours prior to inclusion
2. Age \<18 year old
3. Pregnancy
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