Chlorhexidine and Mupirocin to Prevent Surgical Infections
Decolonization to Reduce After-Surgery Events of Surgical Site Infection
Recruiting
Phase 4
Interventional Study
Surgical Site Infection
Prior Safety Data
This treatment has already been tested in at least one earlier human trial.
At a Glance
- Age
- 18 and older
- Sex
- Any
- Trial phase
- Phase 4
- Study type
- Interventional
- Purpose
- Prevention
- Participants needed
- 2,700 (estimated)
- Sponsor
- University of California, Irvine · Other
Who this trial is looking for
This trial is looking for adults who recently had open abdominal surgery. Participants will wash with a special antiseptic solution after leaving the hospital to see if it helps prevent infections.
Are You a Good Fit for This Trial?
You may be able to join if
- I am 18 years or older
- I had open abdominal surgery within the last 14 days
- I can communicate regularly by phone
- I can bathe or shower, or have help with it
You may not be able to join if
- I was transferred to an acute care hospital
- I was discharged to hospice care
- I was discharged more than 14 days after surgery
- I am allergic to mupirocin or chlorhexidine
- I have an active infection
- My surgical incision was not closed at discharge
Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.
Think this trial could be right for you?
Answer a few quick questions to see if you may meet the eligibility requirements.
Check Your Eligibility
About This Trial
The DECREASE SSI Trial (Decolonization to Reduce After-Surgery Events of Surgical Site Infection) is a two-arm multi-center individual placebo-controlled randomized (2,700 participants randomized 1:1) clinical trial to reduce post-discharge surgical site infection following open colon or small bowel surgery by comparing chlorhexidine bathing plus nasal mupirocin in the 30 days following discharge …
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* 18 years of age or older
* Recent open (not solely laparoscopic) surgery involving an abdominal incision within the past 14 days. For cesarean section, recruitment restricted to BMI ≥ 40.
* Able to communicate regularly by phone
* Able to bathe, shower or have this task perfor…
Contacts