taVNS for FRNS in Children

Recruiting N/A Interventional Study
Nephrotic Syndrome in Children Minimal Change Disease Focal Segmental Glomerulosclerosis
No Placebo Group Every participant receives an active treatment — no one gets a placebo.
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At a Glance
Age
3 – 17
Sex
Any
Study type
Interventional
Purpose
Treatment
Participants needed
30 (estimated)
Sponsor
Northwell Health · Other
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About This Trial
Children with frequently relapsing nephrotic syndrome (FRNS) are exposed to prolonged courses of steroids and other immunosuppressant medications. Given the adverse side effect profiles and variable efficacy of these medications, there is an urgent need to identify novel and safe therapies to treat nephrotic syndrome in children. Stimulation of the vagus nerve, which can be activated non invasivel…
Trial Locations
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Eligibility Criteria
Inclusion Criteria: * FRNS * Age 3-17 years * Glomerular filtration rate (eGFR) ≥30 ml/min/1.73 m2 * Minimal change disease (MCD) or focal segmental glomerulosclerosis (FSGS) diagnosis (clinical diagnosis or per biopsy) * Steroid sensitive nephrotic syndrome (prior history of remission within 4 wee…
Contacts

Christine B Sethna, MD, EdM

718-470-3491

csethna@northwell.edu

CONTACT

Suzanne Vento, RN

718-470-3491

svento@northwell.edu

CONTACT