Sleep Disordered Breathing With Opioid Use
Recruiting
Phase 1
Phase 2
Interventional Study
Sleep Apnea
Opioid Use
Sleep Disordered Breathing
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Prior Safety Data
This treatment has already been tested in at least one earlier human trial.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
At a Glance
- Age
- 18 – 89
- Sex
- Any
- Trial phase
- Phase 1/2
- Study type
- Interventional
- Purpose
- Other
- Participants needed
- 150 (estimated)
- Sponsor
- VA Office of Research and Development · Federal
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About This Trial
There is an increased risk for sleep disordered breathing (SDB), sleep-related hypoventilation and irregular breathing in individuals on chronic prescription opioid medications. Almost 30% of a veteran sleep clinic population had opioid-associated central sleep apnea (CSA). The proposal aims to identity whether oxygen and acetazolamide can be effective in reducing unstable breathing and eliminatin…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Veterans, age 18-89 years
* Veterans with prescription opioids
Exclusion Criteria:
* Patients with BMI\>40kg/m2 will be excluded to avoid the effects of morbid obesity on pulmonary mechanics and ventilatory control
* Patients with history of unresolved/untreated cardiac dise…
Contacts