Re-radiation for Breast Cancer Recurrence
Partial Breast Re-irradiation Using Ultra Hypofractionation (PRESERVE)
Recruiting
N/A
Interventional Study
Breast Cancer
Breast Cancer Recurrent
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
At a Glance
- Age
- 18 – 99
- Sex
- Female
- Study type
- Interventional
- Purpose
- Treatment
- Participants needed
- 171 (estimated)
- Sponsor
- University Health Network, Toronto · Other
Who this trial is looking for
This trial is looking for women with breast cancer that has come back or a new tumor in the same breast after previous radiation treatment. Participants will receive a shorter, one-week course of targeted radiation after surgery.
Are You a Good Fit for This Trial?
You may be able to join if
- I am over 18 years old
- I have in-breast recurrence or a new primary breast cancer
- My tumor is 3.0 cm or smaller
- I completed prior radiation treatment over 5 years ago
- I do not have any cancer in my lymph nodes
- I have clear margins after surgery
- I have healed fully from my surgery
You may not be able to join if
- I have multicentric disease
- My tumor is lobular carcinoma only
- I have T4 disease
- I have positive lymph nodes or metastatic disease
- I have serious non-cancer health issues that prevent me from receiving radiation
- I am currently pregnant or breast-feeding
- I have an implant or pacemaker in my breast
- I cannot start radiation within 16 weeks after surgery
Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
Check Your Eligibility
About This Trial
Breast-conserving surgery followed by re-irradiation with partial breast irradiation (rPBI) has recently been found to be a safe alternative to mastectomy for women who have undergone prior whole breast radiation. By reducing the volume of tissue receiving radiation, rPBI has been associated with less toxicity and improved cosmetic outcomes. For many women with early-stage breast cancer, shorter 1…
Trial Locations
Loading…
Loading trial locations…
Eligibility Criteria
Inclusion Criteria:
* Age \> 18 years
* In-breast recurrence or new primary (ductal carcinoma in situ (DCIS) or invasive carcinoma)
* Tumour \<3.0 cm in greatest diameter on pathologic examination, including both invasive and non-invasive components
* \>5 years after completion of prior adjuvant wh…
Contacts