A Post-market Observational ORIGIN® CR Clinical Study

Inclusion Criteria: * Male and female over 18 years of age * Each patient who is willing to give informed consent. * Clinically indicated for a total knee replacement * Females who are not pregnant and not planning to become pregnant ≤ 12 months. A pregnancy test should be performed for women of childbearing age * Geographically stable and willing to return to the implanting site for all follow-up visits at 1 year and 2 years. Exclusion Criteria: * Acute or chronic, local or systemic infection * Muscular, ligamental, neurological, psychological or vascular deficits * Bone destruction or poor bone quality likely to affect implant stability (requiring a femoral and/or a tibial stem and/or a thick insert) * Any concomitant condition likely to affect implant integration or function * Allergy or hypersensitivity to any of the materials used * For devices in CoCrMo (ISO 5832/4): renal and hepatic impairment * Hip Knee Ankle (HKA) angle \< 165° or \> 195° * Severe collateral ligaments deficiency (requiring a more constrained prosthesis) * Posterior cruciate ligament deficiency * Major anatomical deformities * Severe flexion contracture or severe recurvatum * Revision of a partial or total knee prosthesis * Non-extractible material (e.g. screws, plate, intramedullary nail, osteosynthesis material…) which can create a conflict with any component of the prosthesis * Distal and/or posterior and/or anterior femoral bone loss which exceeds the femoral component thickness * Proximal tibial bone loss which exceeds the tibial component thickness (tibial tray + tibial insert) * Bone degradation requiring an anchoring stem for femoral component