Colonoscopy vs Stool Testing for Older Adults with Polyps
Colonoscopy vs Stool Testing for Older Adults With Colon Polyps
Recruiting
N/AInterventional Study
Colorectal PolypColorectal NeoplasmsColorectal AdenomaColorectal CancerDigestive System Disease
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
65 – 82
Sex
Any
Study type
Interventional
Purpose
Prevention
Participants needed
8,946 (estimated)
Sponsor
Dartmouth-Hitchcock Medical Center · Other
Who this trial is looking for
This trial is looking for older adults aged 65-82 who have had colon polyps. Participants will compare two ways to monitor their health after having polyps: a colonoscopy or a stool test.
Are You a Good Fit for This Trial?
Rules you outColorectal cancerGenetic syndrome for high colorectal cancer riskInflammatory bowel diseaseSevere heart diseaseSevere lung diseaseRecent strokeDementia affecting daily activitiesSevere liver disease
You may be able to join if
I speak English or Spanish
I have a personal history of colorectal polyps
My last colonoscopy showed 2 or fewer non-advanced polyps
I am due for a colonoscopy within the next 12 months
I can provide written informed consent
You may not be able to join if
I have a personal history of colorectal cancer
I have a genetic syndrome that increases my risk for colorectal cancer
I have inflammatory bowel disease
My last colonoscopy showed advanced polyps or 3 or more non-advanced polyps
I am unlikely to benefit from polyp surveillance due to certain health issues
I cannot provide written informed consent
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer a few quick questions to see if you may meet the eligibility requirements.
This is a multi-site comparative effectiveness randomized controlled trial (RCT) comparing annual fecal immunochemical testing (FIT) and colonoscopy for post-polypectomy surveillance among adults aged 65-82 with a history of colorectal polyps who are due for surveillance colonoscopy.
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* English or Spanish speaking
* Personal history of colorectal polyps
* Most recent colonoscopy with ≤2 non-advanced polyps
* Currently due or coming due within 12 months for colonoscopy
* Able to provide written informed consent
Exclusion Criteria:
* Personal history of color…
Inclusion Criteria:
* English or Spanish speaking
* Personal history of colorectal polyps
* Most recent colonoscopy with ≤2 non-advanced polyps
* Currently due or coming due within 12 months for colonoscopy
* Able to provide written informed consent
Exclusion Criteria:
* Personal history of colorectal cancer
* Personal history of genetic syndrome with high risk for colorectal cancer (e.g. Lynch Syndrome, Familial Adenomatous Polyposis Syndrome (FAP), or Serrated Polyposis Syndrome)
* Personal history of inflammatory bowel disease (e.g. ulcerative colitis, Crohn's disease)
* Most recent colonoscopy with advanced polyp(s) or ≥3 non-advanced polyps
* Patients unlikely to benefit from polyp surveillance (e.g., history of heart disease or coronary artery disease with treatment in the last 6 months, heart failure affecting function, lung disease requiring use of home oxygen, stroke within the last 4 months, dementia affecting activities of daily living (ADL) or instrumental activities of daily living (IADL), severe liver disease requiring the use of certain medications to control fluid, confusion, or bleeding, severe kidney disease requiring dialysis, or a new cancer diagnosis within the last year)
* Patients unable to provide written informed consent
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