Bexagliflozin for Obstructive Sleep Apnea in Overweight Adults
Adipose Dysfunction, Imaging, Physiology, and Outcomes With Sodium Glucose Cotransporter 2 Inhibitor (SGLT2i) for Sleep Apnea: The ADIPOSA Study
Recruiting
Phase 4
Interventional Study
Sleep Apnea
Prior Safety Data
This treatment has already been tested in at least one earlier human trial.
At a Glance
- Age
- 18 and older
- Sex
- Any
- Trial phase
- Phase 4
- Study type
- Interventional
- Purpose
- Treatment
- Participants needed
- 164 (estimated)
- Sponsor
- Yale University · Other
Who this trial is looking for
This trial is looking for adults who are overweight or obese and have moderate to severe obstructive sleep apnea. Participants will take either the drug bexagliflozin or a placebo for 6 months while receiving regular care.
Are You a Good Fit for This Trial?
You may be able to join if
- I am overweight or obese.
- I have been diagnosed with obstructive sleep apnea.
- I can provide informed consent and follow study procedures.
You may not be able to join if
- I have conditions not related to obstructive sleep apnea that affect my breathing while sleeping.
- I use sleep-inducing medications.
- I have Type 1 diabetes.
- I have a history of diabetic ketoacidosis.
- I am allergic to bexagliflozin.
- I have severe urinary tract infections.
- I cannot undergo an MRI.
- I am pregnant or breastfeeding.
Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.
Think this trial could be right for you?
Answer a few quick questions to see if you may meet the eligibility requirements.
Check Your Eligibility
About This Trial
The goal of this clinical trial is to test if bexagliflozin lowers the sleep apnea severity in adults who are overweight or obese with moderate to severe obstructive sleep apnea (OSA) compared with a placebo (look-alike substance that contains no active drug).
The main question it aims to answer is:
* If SGLT2i will reduce anatomic and physiologic traits, clinical measures of OSA and sleep defic…
Trial Locations
Loading…
Loading trial locations…
Eligibility Criteria
Inclusion Criteria:
* Able to provide informed consent and stated willingness to comply with all study procedures and availability for the duration of the study
* Overweight or obese (body mass index 25-40 kg/m2)
* Clinically confirmed diagnosis of obstructive sleep apnea by one of the following me…
Contacts