Clinical and Biological Aspects of the MONKEYPOX Disease
Recruiting
N/AInterventional Study
Monkey Pox
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
18 and older
Sex
Any
Study type
Interventional
Purpose
Basic Science
Participants needed
330 (estimated)
Sponsor
Institut Pasteur · Industry
Who this trial is looking for
This trial is looking for adults who are eligible for monkeypox vaccination or have a suspicion of monkeypox infection. Participants will provide a blood sample and must agree to take part in the study.
Are You a Good Fit for This Trial?
You may be able to join if
I am an adult.
I am eligible for monkeypox vaccination or suspected of monkeypox infection.
My health allows me to give a 45 ml blood sample.
I have agreed to participate in the study.
I have Social Health Insurance coverage.
You may not be able to join if
I have been vaccinated for monkeypox without proof.
I have a contraindication to vaccination other than a current infection.
I am pregnant or breastfeeding.
I cannot give informed consent to participate.
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer a few quick questions to see if you may meet the eligibility requirements.
Monkey pox virus (MPXV), of the genus Orthopoxvirus, regularly causes epidemics in endemic areas of central and western Africa.
Since January 1, 2022, cases of Monkey pox have been reported to WHO by 96 Member States in the 6 WHO regions. As of 22 August 2022, a total of 41,664 laboratory-confirmed cases and 192 probable cases, including 12 deaths, have been reported to WHO. Since May 13, 2022, a…
Monkey pox virus (MPXV), of the genus Orthopoxvirus, regularly causes epidemics in endemic areas of central and western Africa.
Since January 1, 2022, cases of Monkey pox have been reported to WHO by 96 Member States in the 6 WHO regions. As of 22 August 2022, a total of 41,664 laboratory-confirmed cases and 192 probable cases, including 12 deaths, have been reported to WHO. Since May 13, 2022, a high proportion of these cases have been reported from countries where monkey pox transmission had not previously been documented. For the first time, cases and sustained chains of transmission are being reported in countries without direct or immediate epidemiological links to areas in West or Central Africa (WHO 2022). France is one of the most affected countries with 2889 cases reported as of August 22, 2022.
This situation led the WHO Director General to declare, on July 23, 2022, that the monkeypox epidemic currently affecting several countries constitutes a Public Health Emergency of International Concern.
To address this epidemic, the WHO has recommended Post Exposure Vaccination (PEP) and Pre Exposure Vaccination (PrEP) for at risk groups with 2nd and 3rd generation vaccines. In France, the Haute Autorité de Santé (French National Authority for Health) recommended on May 20, 2022, vaccination for PEP and on July 7, 2022, for PrEP with a 3rd generation MVA-BN vaccine (Imvanex® or Jynneos®). The European Medicines Agency (EMA) has approved the use of Imvanex® on July 22, 2022 for immunization against MPXV.
The objective of the present study is to describe the clinical, biological, virological, pathophysiological and immunological aspects in the short and medium term of persons vaccinated against and infected with MPXV.
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Eligibility Criteria
Inclusion Criteria:
* Adult,
* eligible for MPXV vaccination according to HAS criteria or suspected of MPXV infection
* whose health status is compatible with a 45 ml single blood sample
* who have consented to participate in the study
* who are covered by a Social Health Insurance plan
Exclusion …
Inclusion Criteria:
* Adult,
* eligible for MPXV vaccination according to HAS criteria or suspected of MPXV infection
* whose health status is compatible with a 45 ml single blood sample
* who have consented to participate in the study
* who are covered by a Social Health Insurance plan
Exclusion Criteria:
* Person with MPXV vaccination without proof of vaccination.
* For persons presenting for MPXV vaccination: presence of a contraindication to vaccination other than a current infection.
* Pregnant and lactating women
* Person unable to give informed consent to participate
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