A Study of Step-up in Bronchial Asthma as a New End Point in Asthma Control (SURFE)

Inclusion Criteria: 1. Able to give written informed consent. 2. Age above 12 years. 3. Ability to use study inhalers correctly, use e-diary, and comply with study procedures and visits. 4. Confirmed diagnosis of mild or moderate asthma asthma (based on GINA defined asthma control on a maximum of maintenance low dose ICS/LABA combination). 5. Pre-bronchodilator ≥FEV1 60%. 6. Reversibility test ≥12% or 200 ml from baseline. 7. Non-smoker. 8. For female subjects, non-pregnant and administer efficient contraception if in childbearing period. Exclusion Criteria: 1. Severe asthma exacerbation in last 3 months. 2. Use of any systemic corticosteroids in last 12 weeks. 3. Use of depot systemic steroids in last 12 weeks. 4. Any concurrent respiratory disease as bronchiectasis, COPD, lung fibrosis, … 5. Current or known history of tuberculosis in any organ. 6. Current malignancy or any history of malignant disease for the past 5 years. 7. Subjects receiving any medications with known drug interaction with study medications. 8. Use of beta-blockers including eye drops. 9. Any significant concurrent disease as cardiac, hepatic, renal, … 10. Current or history of alcohol or drug abuse. 11. Current or history of significant psychiatric disease. 12. Current or history of significant immunodefieciency. 13. History of receiving any biological therapy for asthma for the last 3 years or currently eligible for any biological therapy for asthma. 14. Subjects under any immuno-modulating therapy including biological therapy for any other indication. Subjects may be allowed to participate after 5 times half-live of the concerned drug. 15. Any known allergy or contraindication to any of the study medications.