In Vivo PARP-1 Expression With 18F-FluorThanatrace PET/CT in Patients With Pheochromocytoma and Paraganglioma

Recruiting Early Phase 1 Interventional Study
Pheochromocytoma Paraganglioma
No Placebo Group Every participant receives an active treatment — no one gets a placebo.
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At a Glance
Age
18 and older
Sex
Any
Trial phase
Early Phase 1
Study type
Interventional
Purpose
Diagnostic
Participants needed
30 (estimated)
Sponsor
Heather Wachtel · Other
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About This Trial
This study will enroll up to 30 evaluable patients with pheochromocytoma or paraganglioma who are undergoing surgical or systemic treatment. A pre-treatment 18F-FluorThanatrace (\[18F\]FTT) positron emission tomography/computed tomography (PET/CT) scan will be done prior to surgery or systemic therapy. PET/CT imaging will be used to evaluate PARP-1 expression in sites of pheochromocytoma or para…
Trial Locations
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Eligibility Criteria
Inclusion Criteria: 1. Participants will be ≥ 18 years of age. 2. Clinical diagnosis of pheochromocytoma or paraganglioma based on biochemical and imaging studies At least one lesion identified on standard of care imaging (e.g. CT, MRI, FDG or 68-Gallium dotatate, other PET/CT or MIBG). 3. Standard…
Contacts

Heather Wachtel, MD

215-662-2341

Heather.Wachtel@pennmedicine.upenn.edu

CONTACT

Julia T Lewandowski

215-662-2961

julia.lewandowski@pennmedicine.upenn.edu

CONTACT