A Study of AK129 in Patients With Advanced Malignant Tumors

Inclusion Criteria: 1. The subject must sign the written informed consent form(ICF) voluntarily. 2. Aged ≥ 18 to ≤ 75 years. 3. Eastern Cooperative Oncology Group(ECOG) performance status score of 0 or 1. 4. Life expectancy≥ 3 months. 5. Histologically or cytologically confirmed advanced solid tumors(dose-escalation phase) or selected tumor species(pharmacodynamic confirmation phase and dose-expansion phase);Patients with advanced metastatic malignancies who have failed first-line, or second-line, or third-line, or fourth-line standard therapy, or are ineligible for standard therapy, or cannot tolerate chemotherapy, or are unwilling to receive chemotherapy, or have no effective standard therapy. 6. Pharmacodynamic confirmation phase and dose expansion phase: at least one measurable tumor lesion(RECIST v1.1, lymphoma according to Lugano 2014 evaluation criteria).A lesion from a site previously treated with radiotherapy or other local regional therapy is considered a non-target lesion unless there is definite progression of the lesion or the neoplastic nature of the lesion is confirmed by biopsy. 7. Pharmacodynamic confirmation phase and dose extension phase: All subjects agree to provide archived or freshly obtained tumor tissue samples within 2 years prior to initial administration(formalin-fixed paraffin-embedded (FFPE) tissue wax blocks or approximately 10 unstained tumor tissue sections,and if there is archived tumor tissue within 6 months or 3 months, or freshly obtained tumor tissue, preferably recently obtained tumor tissue samples). 8. The results of laboratory examination during the screening period indicate that the subjects have good organ function:1).Hematology (no supportive treatment of any component blood and cell growth factors were used within 7 days prior to the start of the study):Neutrophil absolute value(ANC)≥1.5×10\^9/L(solid tumors) or 1.0×10\^9/L(lymphoma);Platelet count≥100×10\^9/L(solid tumors) or 75×10\^9/L(lymphoma);haemoglobin≥90 g/L or ≥5.6 mmol/L. 2).Kidney:Serum creatinine(Cr)≤1.5×Upper limit of normal(ULN),or Creatinine clearance \*(CrCl) calculated value≥ 50 mL/min,CrCl was calculated by Cockcroft-Gault formula:CrCl (mL/min)={(140-age)×weight(kg)×F}/(SCr (mg/dL)×72),Male F=1,Female F=0.85,SCr=serum creatinine.3).Liver:Serum total bilirubin(TBil)≤1.5×ULN,Subjects with confirmed/suspected Gilbert disease,TBil ≤ 3× ULN;aspartate aminotransferase(AST) and alanine aminotransferase(ALT) ≤ 2.5×ULN,For subjects with liver metastasis or liver cancer,AST and ALT ≤ 5×ULN.4).Blood clotting function:Internationally standardized ratio(INR)≤ 1.5×ULN and activated partial thromboplastin time(APTT)≤ 1.5×ULN(If the subject is receiving anticoagulant therapy, the subject will receive a steady dose of anticoagulant and the coagulation parameters(prothrombin time(PT)/INR and APTT) will be within the expected range of anticoagulant therapy at the time of screening).5).Cardiac function:Left ventricular ejection fraction(LVEF)≥ 50%;Troponin protein T or I\<2×ULN. 9. Fertile female subjects must undergo a negative serum pregnancy test within 3 days prior to initial medication.If a fertile female subject has sex with an unsterilized male partner, the subject must initiate a highly effective contraceptive method from screening and must agree to continue using these precautions until 120 days after the final administration of the study drug;Periodic abstinence, safe period contraception and extracorporeal ejaculation are not acceptable contraceptive methods; 10. If an unsterilized male subject has sex with a fertile female partner, the subject must use an effective contraceptive method from the beginning of screening to within 120 days after the last dose. Exclusion Criteria: 1. Active central nervous system metastasis. 2. Subjects with uncontrolled pleural effusion, pericardial effusion, or abdominal effusion requiring repeated drainage(frequency greater than monthly). 3. Patients with other active malignant tumors within 2 years prior to the first administration, except for locally curable tumor species and those who have been cured, such as squamous cell carcinoma of the skin, basal cell carcinoma of the skin, superficial bladder carcinoma, and carcinoma in situ of the breast. 4. Known primary or secondary immunodeficiency,including human immunodeficiency virus(HIV) antibodies tested positive. 5. Known history of allogeneic organ transplantation and allogeneic hematopoietic stem cell transplantation. 6. Known interstitial lung disease or non-infectious pneumonia requiring glucocorticoid therapy;Except for those caused by radiation therapy. 7. Severe infections, including but not limited to complications requiring hospitalization, sepsis, or severe pneumonia, occur within 4 weeks prior to initial administration. 8. Present with active infections(including active tuberculosis and active treponema pallidum) requiring systemic treatment, and have used systemic antibacterial, antiviral or antifungal drugs within 2 weeks prior to initial administration;Note: Antiviral drugs for viral hepatitis B are excluded. 9. Subjects with active viral hepatitis B, non-active or asymptomatic hepatitis B virus(HBV) carriers(Hepatitis B surface antigen(HBsAg) positive) with HBV deoxyribonucleic acid(DNA)\>200IU/mL, and subjects with active viral hepatitis C. 10. Have active or documented inflammatory bowel disease(e.g. Crohn's disease, ulcerative colitis), active diverticulitis. 11. Any of the following cardiovascular and cerebrovascular diseases:a.Myocardial infarction, unstable angina pectoris, pulmonary embolism, aortic dissection, deep vein thrombosis, and any arterial thromboembolism events occurred within 6 months prior to initial administration;b.New York Heart Association(NYHA) cardiac functional grade ≥ II for heart failure;c. Severe arrhythmias requiring long-term drug intervention; Subjects with asymptomatic and stable ventricular frequency of atrial fibrillation were admitted.d.Uncontrolled hypertension(defined as systolic blood pressure\>150 mmHg and diastolic blood pressure\>100 mmHg) with sufficient antihypertensive medication, or a history of hypertensive crisis or hypertensive encephalopathy. 12. Received the following antitumor drugs or treatments before initial administration:a. Received monoclonal antibody drugs(including PD-1/L1) immunotherapy drugs within 6 weeks prior to initial administration or within 5 half-time period of the drug, whichever is shorter;b. Received small-molecule targeted drugs, immunomodulatory drugs , Chinese generic drugs with anti-tumor indications, or palliative radiotherapy within 2 weeks prior to initial administration;c. Received other types of antitumor therapy, including chemotherapy, radical radiotherapy, or any unapproved investigational drug within 4 weeks prior to initial dosing;d. Major surgical treatment within 4 weeks prior to initial administration. 13. Dose expansion phase: Immunocheckpoint inhibitors targeting LAG-3 were previously used. 14. Subjects requiring therapy with glucocorticoids(prednisone\>10 mg/ day or equivalent of glucocorticoids) or other immunosuppressive agents within 14 days prior to initial administration;The following are excluded:a. Glucocorticoids as prophylactic drugs for hypersensitivity reactions(such as medication before Computed Tomography(CT) examination). 15. Live vaccine was administered within 4 weeks prior to initial administration. 16. No remission of toxicity from previous antitumor therapy was defined as failure to return to National Cancer Institute Common Terminology Criteria for Adverse Events(NCI CTCAE) v5.0≤1 or the level specified in the inclusion/exclusion criteria(except hair loss). 17. A known history of severe hypersensitivity to other monoclonal antibodies. 18. Any condition that the investigator believes may result in a risk of receiving the study drug or interfere with the evaluation of the study drug or the subject's safety or the interpretation of the study results.