No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
18 and older
Sex
Any
Study type
Observational
Participants needed
225 (estimated)
Sponsor
University of Zurich · Other
Who this trial is looking for
This trial is looking for adults with spinal cord injuries or related conditions. Participants will undergo advanced MRI scans to help understand the effects of their injuries on nervous system function.
Are You a Good Fit for This Trial?
You may be able to join if
I am over 18 years old
I can give informed consent
I am willing to follow the study requirements
I have a chronic spinal cord injury that happened more than 12 months ago
I have degenerative spondylotic myelopathy
I have an acute spinal cord injury that happened less than 2 months ago
I have neurogenic lower urinary tract dysfunction and am receiving tibial nerve stimulation treatment
You may not be able to join if
I am under 18 years old
I cannot undergo MRI due to having a pacemaker or metal in my body
I cannot give informed consent
I have a history of psychiatric or neurological disease not related to my injury
I have had a skull opening or head trauma
I have a history of drug or alcohol abuse
I cannot follow the study procedures due to language or psychological issues
I am pregnant or breastfeeding
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer a few quick questions to see if you may meet the eligibility requirements.
Building on recent improvements, state-of-the-art functional MRI will be applied as an advanced diagnostic tool for the lumbosacral cord in spinal cord injury (SCI) patients to characterize the remaining neuronal activity of the motor and sensory neurons. Alterations in the activity pattern will reveal the effect upon task-related spinal cord activity of the lower motor neurons and sensory neurons…
Building on recent improvements, state-of-the-art functional MRI will be applied as an advanced diagnostic tool for the lumbosacral cord in spinal cord injury (SCI) patients to characterize the remaining neuronal activity of the motor and sensory neurons. Alterations in the activity pattern will reveal the effect upon task-related spinal cord activity of the lower motor neurons and sensory neurons undergoing trauma-induced neurodegeneration, at a spatial specificity that has not been possible so far. Results of this study will be of crucial importance because SCI patients can only profit from regeneration-inducing therapies if spinal neuronal function is preserved below the level of lesion.
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Age \> 18 years
* Informed consent
* Willing to take part and follow requirements of the protocol
Patients additionally need to fulfil the following study-specific inclusion criteria:
Cross-sectional study:
* Chronic traumatic SCI (\> 12 months after injury) or
* Diagnosed …
Inclusion Criteria:
* Age \> 18 years
* Informed consent
* Willing to take part and follow requirements of the protocol
Patients additionally need to fulfil the following study-specific inclusion criteria:
Cross-sectional study:
* Chronic traumatic SCI (\> 12 months after injury) or
* Diagnosed degenerative spondylotic myelopathy (DCM)
Longitudinal study:
* Acute traumatic SCI (\< 2 months after injury) or
* Patients with neurogenic lower urinary tract dysfunction (NLUTD) who undergo routine tibial nerve stimulation (TNS) treatment as part of their rehabilitation (but independently of this study) at Balgrist University Hospital
Exclusion Criteria:
* Age \< 18 years
* Contraindications for MRI (presence of pacemaker or other type of stimulator in the body, presence of metallic foreign body in or on the body, etc.); we will comply with the imaging center's (SCMI) guidelines and in case of doubt we will exclude the participant from the study
* No informed consent
* History of psychiatric or neurological disease, apart from those induced by SCI (e.g.epilepsy)
* History of skull opening or head trauma
* Known or suspected non-adherence, drug or alcohol abuse
* Inability to follow the procedures of the study, e.g. due to language problems, psychological disorders, dementia, etc.
* Women who are pregnant (when uncertain, participants will undergo urine testing) or breastfeeding
* Intention to become pregnant during the course of the study
* Body mass index (BMI) \> 35
* Individuals especially in need of protection (according to Research with Human Subjects published by the Swiss Academy of Medical Sciences)
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