AN69ST Verse PS in CBP in Septic Children

Inclusion Criteria: * Meet the 2005 diagnostic criteria for sepsis * Age 29 days - 18 years old * Sepsis-induced dysfunction of more than one organ or abnormal tissue perfusion, or septic shock * Diagnosis \< 48 hours Exclusion Criteria: * Inability to obtain an informed consent from the subject, family member or an authorized surrogate * Subject has end-stage renal disease and requires chronic dialysis * There is clinical support for non-septic shock * Subject has had chest compressions as part of cardiopulmonary resuscitation this hospitalization without immediate return to communicative state * Subject has uncontrolled hemorrhage * Subject has immunodeficiency diseases * Subject has received chemoradiotherapy or immunosuppressive therapy in the 14 days before enrollment * HIV infection in association with a last known or suspected CD4 count of \<50/mm3 * Subject has sustained extensive third-degree burns within the past 7 days * Subject has known sensitivity or allergy to heparin or has a history of heparin associated thrombocytopenia * Subject is currently enrolled in an investigational drug or device trial * Subject has been previously enrolled in the current trial * Any other condition, that in the opinion of the investigator, would preclude the subject from being a suitable candidate for enrollment, such as end stage chronic illness with no reasonable expectation of survival to hospital discharge * Known hypersensitivity to hemofilter * Subject has received organ transplantation * Subject is expected to die within 24 hours