7 Tesla MRI Brain Imaging to Decipher Filgotinib's Mode of Analgesic Action in Rheumatoid Arthritis
Recruiting
Observational Study
Rheumatoid Arthritis
Sickness Behavior
Inflammatory Disease
Autoimmune
Pain, Chronic
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
At a Glance
- Age
- 18 – 74
- Sex
- Any
- Study type
- Observational
- Participants needed
- 20 (estimated)
- Sponsor
- NHS Greater Glasgow and Clyde · Other
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About This Trial
This is an experimental medicine, single-centre, observational test-retest study to evaluate Filgotinib's mechanism of analgesic action in RA patients.
The investigators hypothesize that Filgotinib's mechanism of analgesic action is determined by at least two factors. The first is related to those CNS sensitization pathways seen in fibromyalgia, specifically DMN-insula brain functional connectivi…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
Patients with moderate to severe active RA who have been prescribed filgotinib in line with the Summary of Product Characterisation and are:
* Adults ≥18 years \< 75 years.
* Right-handed (to reduce neuroimaging heterogeneity).
Exclusion Criteria:
* Inability to provide writt…
Contacts