Amplitude Titration to Improve ECT Clinical Outcomes
Recruiting
N/A
Interventional Study
Depression
ECT
Cognitive Change
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
At a Glance
- Age
- 50 and older
- Sex
- Any
- Study type
- Interventional
- Purpose
- Treatment
- Participants needed
- 50 (estimated)
- Sponsor
- University of New Mexico · Other
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About This Trial
A randomized controlled trial will compare hippocampal neuroplasticity, antidepressant, and cognitive outcomes between individualized amplitude and fixed 800 mA amplitude ECT in older depressed subjects (n = 25 per group, n = 50 total). Relative to fixed 800 mA ECT:
H1: Individualized amplitude arm will have improved RUL antidepressant outcome (IDS-C30 response rates and reduced BT electrode plac…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Diagnosis of major depressive disorder or bipolar II
* Clinical indications for ECT with right unilateral electrode placement
Exclusion Criteria:
* Defined neurological or neurodegenerative disorder (e.g., traumatic brain injury, epilepsy, Alzheimer's disease)
* Other psychi…
Contacts