ECT Treatment for Depression in Older Adults
Amplitude Titration to Improve ECT Clinical Outcomes
Recruiting
N/A
Interventional Study
Depression
ECT
Cognitive Change
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
At a Glance
- Age
- 50 and older
- Sex
- Any
- Study type
- Interventional
- Purpose
- Treatment
- Participants needed
- 50 (estimated)
- Sponsor
- University of New Mexico · Other
Who this trial is looking for
This trial is looking for older adults with depression to compare two different types of ECT treatment. Participants will receive either a standard or personalized level of electrical stimulation during their treatment sessions.
Are You a Good Fit for This Trial?
You may be able to join if
- I have been diagnosed with major depressive disorder or bipolar II
- I have clinical reasons to receive ECT and will have electrodes placed on the right side of my head
You may not be able to join if
- I have a neurological or neurodegenerative disorder like epilepsy or Alzheimer's disease
- I have other psychiatric conditions such as schizophrenia or bipolar I disorder
- I currently have a drug or alcohol use disorder, except for nicotine
- I have contraindications to MRI
Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
Check Your Eligibility
About This Trial
A randomized controlled trial will compare hippocampal neuroplasticity, antidepressant, and cognitive outcomes between individualized amplitude and fixed 800 mA amplitude ECT in older depressed subjects (n = 25 per group, n = 50 total). Relative to fixed 800 mA ECT:
H1: Individualized amplitude arm will have improved RUL antidepressant outcome (IDS-C30 response rates and reduced BT electrode plac…
Trial Locations
Loading…
Loading trial locations…
Eligibility Criteria
Inclusion Criteria:
* Diagnosis of major depressive disorder or bipolar II
* Clinical indications for ECT with right unilateral electrode placement
Exclusion Criteria:
* Defined neurological or neurodegenerative disorder (e.g., traumatic brain injury, epilepsy, Alzheimer's disease)
* Other psychi…
Contacts