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At a Glance
Age
18 and older
Sex
Any
Trial phase
Early Phase 1
Study type
Interventional
Purpose
Basic Science
Participants needed
30 (estimated)
Sponsor
Rhode Island Hospital · Other
Who this trial is looking for
This trial is looking for kidney transplant recipients over 18 who have had skin cancer. Participants will take nicotinamide and vitamin A to see if these supplements can help prevent further skin cancer.
Are You a Good Fit for This Trial?
Must not be takingCarbamazepineAcitretin
Rules you outGorlin's syndromeMetastatic SCCInvasive melanoma
You may be able to join if
I am 18 years old or older.
I have had at least 2 confirmed skin cancers in the past 2 years.
I have had a procedure to remove many skin lesions.
I can read and write in English.
You may not be able to join if
I have liver disease.
I have active peptic ulcer disease.
I have had a heart attack in the last 6 months.
I have low blood pressure.
I have had cancer in the last 5 years.
I have serious kidney problems.
I am pregnant or breastfeeding.
I have used certain skin treatments in the past 6 months.
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
The goal of this clinical trial is to assess the feasibility and safety of oral nicotinamide (NAM; a derivative of vitamin B3 \[niacin\]) and vitamin A in a high-risk population of kidney transplant recipients with a history of skin cancer to generate preliminary data for future cancer prevention clinical trials.
Trial Locations
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Status
Eligibility Criteria
Inclusion Criteria:
* 18 years old or greater;
* Either History of 2 or more histologically confirmed invasive cutaneous SCCs in the past 2 years or
* At least one previously billed Healthcare Common Procedure Coding System code 17004 (destruction of 15 or more benign or premalignant lesions of the…
Inclusion Criteria:
* 18 years old or greater;
* Either History of 2 or more histologically confirmed invasive cutaneous SCCs in the past 2 years or
* At least one previously billed Healthcare Common Procedure Coding System code 17004 (destruction of 15 or more benign or premalignant lesions of the integumentary system);
* Understands, reads, and writes English proficiently.
Exclusion Criteria:
* Liver disease;
* Active peptic ulcer disease;
* Recent myocardial infarction;
* Hypotension;
* Internal malignancy within past 5 years;
* Renal impairment with eGFR\<15 mL/min/1.73 m2;
* Being unable for follow up due to social reasons;
* Gorlin's syndrome or other genetic skin cancer syndrome;
* Huge number of current skin cancers;
* Metastatic SCC or invasive melanoma within the past 5 years;
* Pregnancy or lactation;
* Need for ongoing carbamazepine use (which could have a possible interaction with NAM);
* Use of acitretin or other oral retinoids within the past 6 months;
* Use of supplemental NAM, niacin, vitamin A, or beta carotene within the past 6 months;
* Field treatment for actinic keratoses (AKs) within the previous 4 weeks;
* Use of topical steroids.
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