Pain Relief Comparisons After Common Surgeries
Comparing Analgesic Regimen Effectiveness and Safety for Surgery (CARES) Trial
Recruiting
Phase 4
Interventional Study
Surgery
Pain, Postoperative
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Prior Safety Data
This treatment has already been tested in at least one earlier human trial.
At a Glance
- Age
- 18 and older
- Sex
- Any
- Trial phase
- Phase 4
- Study type
- Interventional
- Purpose
- Treatment
- Participants needed
- 900 (estimated)
- Sponsor
- University of Michigan · Other
Who this trial is looking for
This trial is looking for people who are having specific surgeries to help manage pain after their operation. If you join, you will be assigned to one of two groups to receive different pain relief medications.
Are You a Good Fit for This Trial?
You may be able to join if
- I have not used strong pain medications in the month before my surgery.
- I am having gallbladder removal, hernia repair, or breast lump removal.
You may not be able to join if
- I am scheduled for another surgery within the next 6 months.
- I have serious health issues that could affect my life expectancy.
- I cannot take NSAID medications.
- I cannot take opioid medications.
- I cannot take acetaminophen.
Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
Check Your Eligibility
About This Trial
This trial is being completed to compare two commonly used options to treat pain after surgery. Participants that undergo gallbladder removal, hernia repair, and breast lump removal will be eligible to enroll. Eligible participants will be randomized to 1 of 2 groups of medications (Non-Steroidal Anti-Inflammatory Drugs (NSAIDS) plus acetaminophen or low dose opioids plus acetaminophen).
It is an…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* No significant analgesic medication use before surgery: For this study, significant analgesic medication use before surgery as use of prescriptions for opioid or NSAID medications in the past 30 days, or over-the-counter NSAID use on greater than 7 of 30 past days, as reported…
Contacts