Targeting Breathing Limitations to Improve Functional Outcomes in HFpEF
Recruiting
N/A
Interventional Study
Heart Failure With Preserved Ejection Fraction
Obesity
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
At a Glance
- Age
- 55 – 90
- Sex
- Any
- Study type
- Interventional
- Purpose
- Other
- Participants needed
- 78 (estimated)
- Sponsor
- University of Texas Southwestern Medical Center · Other
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About This Trial
The overall purpose of this study is to investigate whether pulmonary limitations that increase the oxygen (O2) cost of breathing impact dyspnea on exertion (DOE) and peak exercise capacity in patients with HFpEF and obesity. As per investigator's hypothesis, obesity is likely a significant contributor to DOE and exercise intolerance in patients with HFpEF.
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* signs and symptoms of heart failure
* an ejection fraction \> 0.50;
* objective evidence of diastolic dysfunction. elevated biomarkers (NT-proBNP \>300 ng/dl) or HF hospitalization
* healthy volunteers
Exclusion Criteria:
* age \< 55 years
* BMI \> 50 kg/m2
* Atrial fibrilla…
Contacts