Effects of Paroxetine on Cardiovascular Function in Septic Patients
Recruiting
Phase 2
Interventional Study
Septic Shock
Sepsis
Prior Safety Data
This treatment has already been tested in at least one earlier human trial.
At a Glance
- Age
- 18 and older
- Sex
- Any
- Trial phase
- Phase 2
- Study type
- Interventional
- Purpose
- Treatment
- Participants needed
- 92 (estimated)
- Sponsor
- Universidade do Extremo Sul Catarinense - Unidade Academica de Ciecias da Saude · Other
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About This Trial
It is known that septic shock is characterized by arterial hypotension, decreased peripheral vascular resistance and hyporeactivity to vasoconstrictor agents, with NO being an important mediator of this organ dysfunction. Data in the literature have shown that hyporeactivity to catecholamines is associated with a decrease in the density of α and ß receptors in the aorta and heart, respectively, as…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Patient over 18 years of age;
* Patient diagnosed with septic shock for less than 48 hours and using a minimum dose of noradrenaline (0.01 mcg/kg/min);
* Patients and/or legal guardians who consented to participate in the study through the free and informed consent term before…
Contacts