Micro-encapsulated Hepatocyte Intraperitoneal Transplantation in Liver Failure Adults

Inclusion Criteria: A. Chronic liver failure (CLF) group: The progressive liver function decline or decompensation after liver cirrhosis: 1. Body weight\>40kg; 2. Aged between 18 to 65 years old; 3. Serum Total bilirubin was higher than the normal range and lower than 10 times the upper limit of normal value (ULN); 4. With or without significantly decreased serum albumin value, lower than 35; 5. With or without significantly decreased platelet (PLT) value, prothrombin activity (PTA)≤40% (or international normalized ratio (INR)≥1.5), other reasons excluded; 6. With or without refractory ascites or portal hypertension; 7. With or without a stage I or II hepatic encephalopathy; 8. No obvious improvement after more than 3 days' regular clinical treatments. OR B. Acute-on-chronic liver failure (ACLF) group: With known or unknown basic liver diseases, subjects undergoing acute liver failure syndrome (clinical manifestations indicated as an early stage liver failure). 1. Body weight\>40kg; 2. Aged between 18 to 65 years old; 3. With obvious fatigue, accompanied by other gastrointestinal symptoms such as anorexia, vomiting, and abdominal distension; 4. Complicated with ascites and/or hepatic encephalopathy within 4 weeks after being diagnosed; 5. Progressive aggravation of jaundice, total serum bilirubin≥85umol/L； 6. Coagulation disorders, INR\>1.5 or PTA\<40%; 7. No obvious improvement after more than 3 days' regular clinical treatments. Exclusion Criteria: 1. With obvious brain edema, cerebral hernia, or indicated intracranial hemorrhage; 2. Diagnosed or suspected as primary or metastatic liver cancer; 3. With uncorrectable oxygenation index (PaO2/FiO2)\<200; 4. With disseminated intravascular coagulation; 5. Active hemorrhage; 6. Uncontrollable infection, including ascites infection such as spontaneous bacterial peritonitis; 7. Uncorrectable decrease in PLT (\<20×109/L); 8. HIV and/or SARS-CoV-Ⅱ positive; 9. Drug abuse within 1 year; 10. Systemic hemodynamic instability; 11. Combined with pregnancy or lactation; 12. Other situations excluded by clinician;