Linvoseltamab vs Elotuzumab, Pomalidomide, and Dexamethasone

A Trial to Learn How Well Linvoseltamab Works Compared to the Combination of Elotuzumab, Pomalidomide and Dexamethasone for Adult Participants With Relapsed/Refractory Multiple Myeloma

Recruiting Phase 3 Interventional Study
Relapsed Refractory Multiple Myeloma (RRMM)
No Placebo Group Every participant receives an active treatment — no one gets a placebo. Pivotal Trial This treatment is in the last trial phase before FDA approval. Prior Safety Data This treatment has already been tested in at least one earlier human trial.
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At a Glance
Age
18 and older
Sex
Any
Trial phase
Phase 3
Study type
Interventional
Purpose
Treatment
Participants needed
410 (estimated)
Sponsor
Regeneron Pharmaceuticals · Industry
Who this trial is looking for

This trial is looking for adults with relapsed or refractory multiple myeloma who need additional treatment after previous therapies. Participants will either receive linvoseltamab or a combination of elotuzumab, pomalidomide, and dexamethasone.

Are You a Good Fit for This Trial?
Must be taking LenalidomideProteasome inhibitor

You may be able to join if

  • I am 18 years old or older.
  • I have had 1 to 4 prior treatments for my multiple myeloma.
  • I have measurable disease for response assessment.
  • I have good blood and liver function.
  • I have a life expectancy of at least 6 months.

You may not be able to join if

  • I have been diagnosed with plasma cell leukemia or amyloidosis.
  • I have received elotuzumab or pomalidomide before.
  • I have known brain lesions or meningeal involvement.
  • I have received systemic anti-cancer therapy within the last 28 days.
  • I had a stem cell transplant within the last 6 months.
  • I have a history of progressive multifocal leukoencephalopathy.
  • I have an uncontrolled infection with HIV, hepatitis B, or hepatitis C.
  • My heart function is below 40%.

Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.

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About This Trial
This study is researching an experimental drug called linvoseltamab, also called REGN5458. Linvoseltamab has previously been studied by itself (without other cancer drugs) in participants who had advanced multiple myeloma that returned and needed to be treated again after many other therapies had failed. These participants were no longer benefiting from standard medications and had no good treatm…
Trial Locations
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Eligibility Criteria
Key Inclusion Criteria: 1. Age 18 years or older (or legal adult age in the country) at the time of the screening visit. 2. Eastern Cooperative Oncology Group (ECOG) performance status ≤1. Patients with ECOG 2 solely due to local symptoms of myeloma (eg. pain) may be allowed after discussion with t…
Contacts

Clinical Trials Administrator

844-734-6643

clinicaltrials@regeneron.com

CONTACT