Transitional Care for Chronic Liver Disease Patients
A Trial of Post-Discharge Transitional Care for Patients With Chronic Liver Disease
Recruiting
N/AInterventional Study
Liver Diseases
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
18 and older
Sex
Any
Study type
Interventional
Purpose
Treatment
Participants needed
1,000 (estimated)
Sponsor
Indiana University · Other
Who this trial is looking for
This trial is looking for adults with advanced liver disease who are about to leave the hospital. Participants will receive a special care program to help improve their recovery and avoid going back to the hospital.
Are You a Good Fit for This Trial?
You may be able to join if
I am at least 18 years old.
I have been diagnosed with advanced liver disease.
I have had complications during my hospital stay.
I am planned to be discharged to home or a facility within 72 hours.
I am able to provide informed consent.
You may not be able to join if
I am being discharged under hospice care.
I am on the liver transplant list with a high MELD-Na score.
I cannot participate in follow-up care.
I do not speak or understand English or Spanish.
I have low hearing or communication ability that would interfere.
I do not have access to a telephone.
I am currently incarcerated.
I am enrolled in another interventional research study.
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
Patients with complications of advanced liver disease often have difficulties after hospital discharge that result in early hospital readmission. Poor outcomes for these patients during this transitional time could be improved through the use of innovative transitional care models. This proposal aims to examine the effect of a transitional care model, The Transitional Liver Clinic (TLC), in reduci…
Patients with complications of advanced liver disease often have difficulties after hospital discharge that result in early hospital readmission. Poor outcomes for these patients during this transitional time could be improved through the use of innovative transitional care models. This proposal aims to examine the effect of a transitional care model, The Transitional Liver Clinic (TLC), in reducing hospital re-admissions, improving quality of life, and improving patient experience.
Trial Locations
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Status
Eligibility Criteria
Inclusion Criteria:
1. Male or female age ≥18
2. Diagnosis of advanced liver disease, defined as either (must meet either a or b)
1. cirrhosis based on (either i or ii):
* biopsy
* characteristic clinical, laboratory, and imaging findings
2. acute alcoholic hepatitis, defined by…
Inclusion Criteria:
1. Male or female age ≥18
2. Diagnosis of advanced liver disease, defined as either (must meet either a or b)
1. cirrhosis based on (either i or ii):
* biopsy
* characteristic clinical, laboratory, and imaging findings
2. acute alcoholic hepatitis, defined by NIAAA Alcoholic Hepatitis Consortia, as
* onset of jaundice (serum bilirubin \>3.0 mg/dL) in prior 8 weeks
* consumption of \>40 (female) or 60 (male) g alcohol/day for ≥6 months, with \<60 days abstinence before jaundice onset,
* AST\>50 IU/L, AST/ALT\>1.5, and both values \<400 IU/L
* liver biopsy confirmation in patients with confounding factors
3. Has at least one of the following complications due to advanced liver disease occurring during hospitalization:
1. ascites requiring diuretics or paracentesis
2. hepatic encephalopathy requiring lactulose or rifaximin
3. gastrointestinal bleeding due to portal hypertension
4. jaundice
4. Has planned discharge alive to home or a facility within 72 hours of informed consent
5. Able and willing to provide informed consent
Exclusion Criteria:
1. discharge under hospice
2. listed for liver transplant with MELD-Na ≥ 35
3. unable or unwilling to participate in post-discharge follow-up either in-person or virtually
4. unable to speak or understand English and/or Spanish
5. low hearing or communicative ability (examiner rated) that would interfere with interventions and outcome assessments
6. lack of access to a telephone
7. incarcerated
8. concurrent enrollment in an interventional research study
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