No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
35 and older
Sex
Any
Study type
Observational
Participants needed
100 (estimated)
Sponsor
Roskamp Institute Inc. · Other
Who this trial is looking for
This trial is looking for veterans who served in the Gulf War and are 35 years or older. Participants will help researchers identify blood markers related to Gulf War Illness and cognitive decline.
Are You a Good Fit for This Trial?
You may be able to join if
I am 35 years old or older.
I served in the Gulf War from 1990 to 1991 as active duty, national guard, or reserves.
I meet the CDC definition of Gulf War Illness.
I can understand written and spoken English or have someone who can help me understand.
I am a veteran in the same age range as those with Gulf War Illness.
You may not be able to join if
I have been diagnosed with cancer (other than non-melanoma skin cancers).
I have a chronic infectious disease.
I have problems from postwar injuries.
I have liver disease.
I have lupus.
I have multiple sclerosis.
I have had a serious psychiatric condition or hospitalization since 1991.
I am pregnant or nursing.
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
The investigators goals are to identify blood lipids/metabolites that correlate with cognitive decline in the presence of the APOE ε4 allele among veterans with GWI. To determine the effect of dietary, medical and biological factors that influence lipid and metabolites in blood from GW veterans. To identify blood lipid/metabolite profiles that correlate with bioenergetics deficits and glial activa…
The investigators goals are to identify blood lipids/metabolites that correlate with cognitive decline in the presence of the APOE ε4 allele among veterans with GWI. To determine the effect of dietary, medical and biological factors that influence lipid and metabolites in blood from GW veterans. To identify blood lipid/metabolite profiles that correlate with bioenergetics deficits and glial activation in the brains of GWI. To validate blood biomarker signatures of GWI using APOE genotyping and blood lipids/metabolites that correlate with the CNS dysfunction in GWI.
Trial Locations
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Status
Eligibility Criteria
Inclusion Criteria:
1. Age 35 years or older.
2. For GWI cases, served in the 1990-1991 Gulf War as active duty, national guard, or reserves and meet criteria for the CDC Chronic Multisymptom Illness (CMI) GWI definition or Kansas GWI definition.
3. For controls, must be a veteran in the same age r…
Inclusion Criteria:
1. Age 35 years or older.
2. For GWI cases, served in the 1990-1991 Gulf War as active duty, national guard, or reserves and meet criteria for the CDC Chronic Multisymptom Illness (CMI) GWI definition or Kansas GWI definition.
3. For controls, must be a veteran in the same age range as those veterans with GWI as defined above.
4. Ability to understand written and spoken English or availability of a legal representative who can understand written or spoken English. Participants and caregiver/informants must be able to read, write and speak the language in which psychometric tests are provided with visual and auditory acuity (corrected) sufficient to allow for accurate testing.
Exclusion Criteria:
1. Diagnosed or being treated by a physician for any of the following (Steele et al, 2000) and deemed clinically significant per the discretion of the PI:
1. Cancer (except for non-melanoma skin cancers)
2. Chronic infectious disease
3. Problems resulting from postwar injuries.
4. Liver disease
5. Lupus
6. Multiple sclerosis
7. Stroke
8. Serious psychiatric condition (those associated with psychosis and/or for which the respondent had been hospitalized since 1991).
9. Dementia or any type of Parkinson's disease (PD).
2. Hospitalized in the last 5 years for alcohol or drug dependence, depression, or post-traumatic stress disorder (PTSD).
3. Female subject is either pregnant or nursing.
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