Smallpox Vaccine for Mpox Post-Exposure Prophylaxis: A Cluster RCT
Recruiting
Phase 4
Interventional Study
Monkeypox
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Prior Safety Data
This treatment has already been tested in at least one earlier human trial.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
At a Glance
- Age
- 2 and older
- Sex
- Any
- Trial phase
- Phase 4
- Study type
- Interventional
- Purpose
- Prevention
- Participants needed
- 3,000 (estimated)
- Sponsor
- McMaster University · Other
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About This Trial
A cluster randomized controlled trial to determine if smallpox vaccine reduces secondary cases and symptom severity in persons exposed to mpox.
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
1. Household member of person with laboratory confirmed mpox
2. Age ≥ 2 years
3. Within 14 days of onset of illness in mpox index case
Exclusion Criteria:
1. Pregnancy
2. Breastfeeding
3. Past serious allergic reaction to study vaccine components
4. Previous smallpox vaccinati…
Contacts