At High-risk for Pre-eclampsia After Assisted Reproductive Technology

Inclusion Criteria: * First time oocyte acceptors Or Nulliparous PCOS patients undergoing ART (IVF/ICSI) * Criteria for PCOS: two out of the three following criteria must be present: 1. Oligo-or anovulation: a menstrual cycle \>35 days 2. Hyperandrogenism: * Clinically: the presence of hirsutism and/ or severe acne in combination with alopecia confirmed hyperandrogenism Or * Biochemically: serum total testosterone \>52 ng/dl or calculated free testosterone \>0,64 ng/dl 3. Polycystic ovaries: * Follicle number per ovary (FNPO) ≥ 12 on both ovaries Or * Ovarian volume ≥ 10 ml in both ovaries Or * One ovary with ≥ 20 follicles (Using endovaginal US transducers with a frequency bandwidth that includes 8 MHz) Or * AMH ≥ 4,9 ng/ml Exclusion Criteria: * Known essential hypertension or development of a new-onset hypertension before 20 weeks' gestation * Hypertension is defined as a systolic blood pressure ≥ 140 or a diastolic blood pressure ≥ 90 on two separate measurements with at least 20 minutes in between, taken when the patients is in a seated position Or * The patient is known with hypertension, diagnosed by a certified doctor * Known diabetes type 1 or 2 before pregnancy * Diagnosis of diabetes is confirmed when one of the following is present: * Fasting glucose ≥ 126 mg/dl * A 2-hour plasma glucose level ≥ 200 mg/dL during a 75-g oral glucose tolerance test Or * The patient is known with diabetes (type 1 or 2), diagnosed by a certified doctor * Thyroid dysfunction not under control with medication: * Hyperthyroidism, the diagnoses is made when: * Peripheral blood TSH \<0,5 mIU/L and fT4 \>1,9 ng/dl Or * When the patient is known with hyperthyroidism diagnosed by a certified physician * Hypothyroidism, the diagnosis is made when: * Peripheral blood TSH \>5 mIU/L and fT4 \<0,7 ng/dl Or * When the patient is known with hypothyroidism diagnosed by a certified physician * Other endocrinological disorder (including Cushing syndrome, Adrenal insufficiency, acromegaly): for diagnosis we will trust the opinion of the certified endocrinologist * Cardiovascular diseases (including coronary artery disease, arrhythmia, heart valve disease and heart failure): for diagnosis we will trust the opinion of the certified cardiologist * Renal disease/insufficiency: for diagnosis we will trust the opinion of the certified nephrologist * Systemic lupus erythematosus: for diagnosis we will trust the opinion of the certified internal medicine doctor * Antiphospholipid syndrome: for diagnosis we will trust the opinion of the certified internal medicine doctor * Liver dysfunction/disease: for diagnosis we will trust the opinion of the certified gastroenterologist * History of prior pre-eclampsia * Women pregnant with a fetus with known abnormalities such chromosomal anomalies, structural deformities of limbs or organs or any other prebirth diagnosed syndromes or defects * Multiple pregnancy