No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
18 and older
Sex
Any
Study type
Observational
Participants needed
800 (estimated)
Sponsor
Brown University · Other
Who this trial is looking for
This trial is looking for people with current acute or chronic pain, as well as healthy individuals. Participants will use a smartphone app to report daily pain and mood for four months.
Are You a Good Fit for This Trial?
You may be able to join if
I am over 18 years old.
I have a personal smartphone and stable internet.
I have had pain for more than 6 months or I have pain for less than 3 months due to recent surgery, injury, acute illness, or childbirth.
I currently have chronic low back pain, failed back surgery syndrome, or fibromyalgia.
You may not be able to join if
I have had a surgery or injury unrelated to my pain in the past 3 months.
I have a history of chronic pain lasting more than 6 months.
I am not fluent in English.
I have current primary or metastatic cancer.
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
This study relies on the use of a smartphone application (SOMA) that the investigators developed for tracking daily mood, pain, and activity status in acute pain, chronic pain, and healthy controls over four months.The primary goal of the study is to use fluctuations in daily self-reported symptoms to identify computational predictors of acute-chronic pain transition, pain recovery, and/or chronic…
This study relies on the use of a smartphone application (SOMA) that the investigators developed for tracking daily mood, pain, and activity status in acute pain, chronic pain, and healthy controls over four months.The primary goal of the study is to use fluctuations in daily self-reported symptoms to identify computational predictors of acute-chronic pain transition, pain recovery, and/or chronic pain maintenance or flareups. The general study will include anyone with current acute or chronic pain, while a smaller sub-study will use a subset of patients from the chronic pain group who have been diagnosed with chronic low back pain, failed back surgery syndrome, or fibromyalgia. These sub-study participants will first take part in one in-person EEG testing session while completing simple interoception and reinforcement learning tasks and then begin daily use of the SOMA app. Electrophysiologic and behavioral data from the EEG testing session will be used to determine predictors of treatment response in the sub-study.
Trial Locations
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Status
Eligibility Criteria
INCLUSION CRITERIA \[General study\]
* Chronic pain group:
* Age above 18
* Access to a personal smartphone and a stable internet connection
* Average pain intensity score of greater than 3 in the past week or
* Average pain interference score of greater than 3 in the past week or
* Aver…
INCLUSION CRITERIA \[General study\]
* Chronic pain group:
* Age above 18
* Access to a personal smartphone and a stable internet connection
* Average pain intensity score of greater than 3 in the past week or
* Average pain interference score of greater than 3 in the past week or
* Average pain distress score of greater than 3 in the past week
* Pain duration: greater than 6 months
* Acute pain group:
* Age above 18
* Access to a personal smartphone and a stable internet connection
* Average pain intensity score of greater than 3 in the past week
○ or
* Average pain interference score of greater than 3 in the past week
○ or
* Average pain distress score of greater than 3 in the past week
* Pain duration: less than 3 months
* Pain cause: Due to recent surgery, injury, acute illness, or childbirth (within the past 3 months)
* Healthy control group:
* Age above 18
* Access to a personal smartphone and a stable internet connection
* Average pain intensity score of less than 3 in the past week
* Average pain interference score of less than 3 in the past week
* Average pain distress score of less than 3 in the past week
* No surgery, injury, acute illness, or childbirth (within the past 3 months)
* In person EEG testing \[Sub-Study only\]:
* Same as in General App Study Above and additionally:
* Current diagnosis of Fibromyalgia, Chronic Low Back Pain or Failed Back Surgery Syndrome OR
* No current or prior history of chronic pain
* If participant has chronic low back pain or failed back surgery syndrome: are they planning to have either a radio-frequency ablation, back surgery, or spinal cord stimulation implant in the next few months
* If participant has chronic low back pain or failed back surgery syndrome: have they received insurance approval for the procedure?
* Ok with EEC/ECG measures
EXCLUSION CRITERIA \[General study\]
* Chronic pain group:
* recent injury or surgery unrelated to the pain in the past 3 months
* difficulty participating for technical/logistical issues (e.g., no computer, incompatible smartphone, can't commit to 4 months study participation);
* Not fluent in English (difficulty understanding questions)
* Current primary or metastatic cancer (organic cause of pain)
* Acute pain group:
* History of Chronic Pain (Pain lasting for more than 6 months)
* difficulty participating for technical/logistical issues (e.g., no computer, incompatible smartphone, can't commit to 4 months study participation);
* Not fluent in English (difficulty understanding questions)
* Current primary or metastatic cancer (organic cause of pain)
* Healthy control group:
History of Chronic Pain (Pain lasting for more than 6 months)
* difficulty participating for technical/logistical issues (e.g., no computer, incompatible smartphone, can't commit to 4 months study participation);
* Not fluent in English (difficulty understanding questions)
-In person EEG testing \[Sub-study only\]: \[will interfere with EEG data collection safety or quality\]:
* Same as in General App Study Above and additionally:
* Baldness
* Pregnancy
* Dreadlocks
* Left-handedness
* Use of a wheelchair
* Heart failure diagnosis
* Current or prior experience with acute psychosis or mania
* implanted pacemaker, neurostimulator or any other head or heart implants
* require a hearing aid to hear properly
* claustrophobia
* metal fragments in the body
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