No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
18 and older
Sex
Any
Study type
Observational
Participants needed
150 (estimated)
Sponsor
Yale University · Other
Who this trial is looking for
This trial is looking for patients who have had a recent ischemic stroke. Participants will be assessed to understand how changes in blood pressure impact recovery and to find better treatment options.
Are You a Good Fit for This Trial?
You may be able to join if
I have been diagnosed with ischemic stroke.
I have imaging results showing ischemic stroke in specific brain areas.
My stroke started within the last 48 hours.
I can have a special MRI scan within 72 hours of arriving at the hospital.
I have a NIH Stroke Scale score of 4 or higher.
You may not be able to join if
I had a pre-existing disability rating of 3 or higher before my stroke.
I am not expected to stay in the hospital for at least 72 hours.
I have a pacemaker or other reasons that prevent me from having an MRI.
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
The goal of this observational study is to evaluate the role of blood pressure (BPV) variability in patients suffering from acute ischemic stroke. The main questions it aims to answer are:
1. To determine the association of BPV with functional/cognitive outcome after ischemic stroke.
2. To determine a pathophysiologic mechanism of BPV's deleterious effect on functional outcome.
3. To evaluate pot…
The goal of this observational study is to evaluate the role of blood pressure (BPV) variability in patients suffering from acute ischemic stroke. The main questions it aims to answer are:
1. To determine the association of BPV with functional/cognitive outcome after ischemic stroke.
2. To determine a pathophysiologic mechanism of BPV's deleterious effect on functional outcome.
3. To evaluate potential treatment targets to pharmacologically reduce BPV after ischemic stroke.
Trial Locations
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Status
Eligibility Criteria
Inclusion Criteria:
* Ischemic stroke according to the American Heart Association (AHA) definition and either:
1. CT or MRI showing ischemic stroke in the anterior circulation (frontal, parietal or superior temporal lobes), or
2. Occlusion of the internal carotid, middle cerebral or anterior c…
Inclusion Criteria:
* Ischemic stroke according to the American Heart Association (AHA) definition and either:
1. CT or MRI showing ischemic stroke in the anterior circulation (frontal, parietal or superior temporal lobes), or
2. Occlusion of the internal carotid, middle cerebral or anterior cerebral arteries on computed tomography angiography (CTA) or magnetic resonance angiography (MRA)
Onset of ischemic stroke within 48 hours and able to get baseline pMRI within 72 hours of arrival
4\) NIH Stroke Scale ≥ 4 at time of enrollment
Exclusion Criteria:
* Pre-morbid mRS ≥3
* Predicted hospital system admission \<72 hours
* Pacemaker or other MRI contraindications per American College of Radiology guidelines
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