Solid Tumors in RASopathies
Recruiting
N/A
Interventional Study
RASopathy
Costello Syndrome
Cardio-Facio-Cutaneous Syndrome
Noonan Syndrome
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
At a Glance
- Sex
- Any
- Study type
- Interventional
- Purpose
- Diagnostic
- Participants needed
- 100 (estimated)
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS · Other
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About This Trial
RASopathies are a group of syndromes, caused by variants of genes involved in the regulation of the Ras/MAP/ERK pathway. This intracellular transduction pathway profoundly affects embryogenic development, organogenesis, synaptic plasticity and neuronal growth.
RASopathies are characterized by multi-organ involvement, growth delay, premature aging and haemato-oncological manifestations.
Based on …
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Clinical and molecularly confirmed diagnosis of a RASopathy
Exclusion Criteria:
* Clinical diagnosis of RASopathy without molecular characterization
Contacts