Oxygen Toxicity: Mechanisms in Humans

Recruiting N/A Interventional Study
Oxygen Toxicity Hypercapnia Seizures
No Placebo Group Every participant receives an active treatment — no one gets a placebo. Healthy Volunteers Welcome You do not need to have the condition being studied to take part.
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At a Glance
Age
18 – 45
Sex
Any
Study type
Interventional
Purpose
Prevention
Participants needed
62 (estimated)
Sponsor
Duke University · Other
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About This Trial
The goal of this clinical trial is to learn about the mechanisms of oxygen toxicity in scuba divers. The main questions it aims to answer are: * How does the training of respiratory muscles affect oxygen toxicity? * How do environmental factors, such as sleep deprivation, the ingestion of commonly utilized medications, and chronic exposure to carbon dioxide, impact the risk of oxygen toxicity? * …
Trial Locations
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Eligibility Criteria
Inclusion Criteria: * Equal numbers of male and female * Non-smokers * Aged 18-45 years * Males will be required to have VO2 peak \> or equal to mL/kg min * and females \> or equal to 30 mL/kg min Exclusion Criteria: * Pregnancy * Cardiorespiratory disease, including hypertension * Neuromuscular …
Contacts

Derek B Covington, MD

919-613-8881

derek.covington@duke.edu

CONTACT

Richard Moon, MD

919-613-8881

Richard.moon@duke.edu

CONTACT