Genetic and Epigenetic Variations in Heterokaryotypic Monozygotic Twins Discordant for Down Syndrome
Recruiting
N/A
Interventional Study
Down Syndrome
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
At a Glance
- Age
- 4 – 11
- Sex
- Male
- Study type
- Interventional
- Purpose
- Basic Science
- Participants needed
- 5 (estimated)
- Sponsor
- Institut Jerome Lejeune · Other
Think this trial could be right for you?
Answer a few quick questions to see if you may meet the eligibility requirements.
Check Your Eligibility
About This Trial
Heterokaryotypic monozygotic twins discordant for Down syndrome (DS) are very rare, with an incidence estimated to be less than 1 over 7,000,000 pregnancy in the general population. Sharing the same genetic patrimony, except for an additional chromosome 21 for one of them, any gene-expression difference between them could be attributed only to the supernumerary chromosome 21 and not to polymorphic…
Trial Locations
Loading…
Loading trial locations…
Eligibility Criteria
Inclusion Criteria:
* Twins of a heterokaryotypic monozygotic pair discordant for DS
* Twins of a sex- and class of age-matched dizygotic pair discordant for DS,
* Sex- and class of age-matched patient with mosaic T21
* Subject's parents/legal representatives willing to give written informed consen…
Contacts