Therapeutic Cancer Vaccine (AST-301, pNGVL3-hICD) in Gastric Cancer
Recruiting
Phase 2
Interventional Study
Gastric Cancer
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Prior Safety Data
This treatment has already been tested in at least one earlier human trial.
At a Glance
- Age
- 18 – 85
- Sex
- Any
- Trial phase
- Phase 2
- Study type
- Interventional
- Purpose
- Treatment
- Participants needed
- 24 (estimated)
- Sponsor
- Aston Sci. Inc. · Industry
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About This Trial
The purpose of this early proof-of-concept study to evaluate the safety and immunologic efficacy of AST-301 in gastric cancer patients with HER2 expression (including both HER2 low expression and overexpression) who have completed the standard adjuvant treatment (including those who discontinued the standard adjuvant treatment due to intolerance).
Participants will be randomized 1:1 to either Arm…
Trial Locations
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Eligibility Criteria
Key Inclusion Criteria:
* Underwent a curative surgery with standard lymph node dissection (confirmed with no residual tumor, R0 resection) and have completed standard adjuvant treatment
* Has stages II or III according to the 8th edition of the American Joint Committee on Cancer (AJCC)
* HER2 low …
Contacts