A Study of XZB-0004 in Patients With Solid Tumors

Inclusion Criteria: 1. Patient has signed informed consent before any trial related activities. 2. Be 18 years of age or older and less than 75 years at the time of signing the informed consent. 3. Part 1: Have a histologically or cytologically confirmed diagnosis of a solid tumour malignancy; Part 2：Have a histologically or cytologically confirmed diagnosis of a NSCLC or solid tumour malignancy. 4. Have evaluable (for Part 1) or measurable (for Part 2) disease as the Response Evaluation Criteria in Solid Tumours (RECIST) 1.1. 5. Have a performance status score of 0 or 1 according to the Eastern Cooperative Oncology Group (ECOG) scale. 6. Have adequate organ function. 7. Have recovered to ≤ grade 1 or Meet the requirements of the study from the effects of any prior cancer therapy, except for alopecia; irreversible neuropathy should have recovered to ≤ grade 2. 8. Have a life expectancy greater than 3 months. 9. Eligible patients (male and female) who are fertile must agree to at least use a reliable contraceptive method with partner. 10. Willingness to comply with scheduled visits, treatment plans, laboratory tests, and other study procedures. Exclusion Criteria: 1. Previous use of AXL inhibitors and immunotherapy was consistent with protocol requirements. 2. Received anti-tumor therapy such as chemotherapy, radiotherapy, biotherapy, endocrine therapy, immunotherapy or other therapy within 4 weeks prior to the first dose of the investigational drug. 3. Received other unmarketed investigational drugs or treatments within 4 weeks or 5 times the elimination half-life prior to the first dose of the investigational drug. 4. Treatment with systemic glucocorticoids (prednisone \> 10mg per day or equivalent) or other immunosuppressive agents within 14 days before the first dose of a trial drug. 5. Inability to swallow, intestinal obstruction or other factors that affect the taking and absorption of the drug. 6. Patient with heart function impaired or clinically significant heart disease. 7. Any condition or illness that, in the opinion of the Investigator, would interfere with the evaluation of the safety of the study drug. 8. History of immune deficiencies, including positive HIV antibody tests. 9. Patient is in the active stage of HBV or HCV. 10. History of solid organ transplant or bone marrow transplant. 11. Any other malignant tumor has been diagnosed within 5 years. 12. Has known Primary tumor of the central nervous system or central nervous system metastase. 13. Uncontrolled pleural effusion, pericardial effusion, or ascites requiring repeated drainage were present within 4 weeks before the first dose of the trial drug. 14. Subjects with psychiatric disorders that may affect trial compliance. 15. history of Alcoholism or drug abuse. 16. Pregnant or breastfeeding. 17. The researchers considered that there were some cases that were not suitable for inclusion.