No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Prior Safety Data
This treatment has already been tested in at least one earlier human trial.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
40 – 89
Sex
Any
Trial phase
Phase 1/2
Study type
Interventional
Purpose
Other
Participants needed
60 (estimated)
Sponsor
Texas Tech University Health Sciences Center · Other
Who this trial is looking for
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To test how two weeks of curcumin supplementation would cross the blood brain barrier (BBB) and attach to amyloid beta proteins, to assess the feasibility (safety and bioavailability), and to explore the resulting abundance/composition of gut microbiota.
Trial Locations
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Eligibility Criteria
Inclusion:
* Both male and female, age 40 - 89 years.
* Diagnosed with Aβ deposits in retina (peripheral superior quadrants)--to be confirmed after consent obtained. If there is documentation the potential participant has been diagnosed with Aβ deposits in retina within 6 months before the consent …
Inclusion:
* Both male and female, age 40 - 89 years.
* Diagnosed with Aβ deposits in retina (peripheral superior quadrants)--to be confirmed after consent obtained. If there is documentation the potential participant has been diagnosed with Aβ deposits in retina within 6 months before the consent session, we will use this diagnosis/documentation for eligibility criteria. Otherwise, the ophthalmic exam will be repeated after consent is obtained for the study.
* No pre-existing liver or kidney diseases by self-report.
Exclusion:
* Patients with ocular diseases (macular degeneration, severe diabetes retinopathy)
* Had used systemic antibiotics within 1 month prior to the start of the study intervention
* Had taken any turmeric or curcumin products within 2 weeks prior to the start of the study intervention
* Had a known allergy to black pepper
* Women that are pregnant or breastfeeding
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